4-(Trifluoromethyl)-4-piperidinecarboxylic acid CAS 1260790-32-6
| CAS No. | 1260790-32-6 |
| Molecular Formula | C7H10F3NO2 |
| Molecular Weight | 197.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-(Trifluoromethyl)-4-piperidinecarboxylic acid (CAS 1260790-32-6), molecular formula C7H10F3NO2 and molecular weight 197.16 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(Trifluoromethyl)-4-piperidinecarboxylic acid (C7H10F3NO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H10F3NO2 |
| Molecular Weight | 197.16 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 6-(Trifluoromethyl)piperidine-3-carboxylic acid (CAS 1155103-14-2)
- Methyl 4-(trifluoromethyl)pyrrolidine-3-carboxylate (CAS 1190043-09-4)
- 7-(Trifluoromethyl)isoquinoline (CAS 1194375-56-8)
- 6-(Trifluoromethyl)isoquinoline (CAS 1194375-62-6)
- 4-(Trifluoromethyl)isoquinoline (CAS 120568-08-3)
- 8-(trifluoromethyl)isoquinoline (CAS 120568-10-7)
- 2-(Trifluoromethyl)piperidine-3-carboxylic acid (CAS 1240528-93-1)
- 2-(5-(Trifluoromethyl)pyrrolidin-2-yl)acetic acid (CAS 1258640-31-1)
Recommended Standards
- 3,3,3-Trifluoro-2-hydroxy-1-(pyrrolidin-1-yl)propan-1-one (CAS 125969-74-6)
- 1-(4-Fluoro-2-nitrophenyl)propan-2-one (CAS 1263279-70-4)
- 1-(5-Fluoro-2-nitrophenyl)propan-2-one (CAS 1266659-06-6)
- 2-Amino-3-(2-(trifluoromethyl)cyclopropyl)propanoic acid (CAS 1251922-69-6)
- (4-Oxo-4H-benzo[4,5]thiazolo[3,2-a]pyrimidin-2-yl)methyl 2-(4,4-diethyl-2,5-dioxoimidazolidin-1-yl)acetate (CAS 792965-51-6)
- Methyl 5-((4-methoxybenzyl)amino)pyrazine-2-carboxylate (CAS 1204527-84-3)
- 2-(2-Bromo-4-formyl-6-methoxyphenoxy)acetamide (CAS 692268-00-1)
- 2-Chloro-6-cyano-5-(difluoromethyl)pyridine-3-sulfonamide (CAS 1805258-31-4)
- Rosuvastatin Impurity 65 (CAS 885477-83-8)
- cis-3-(2-Thiomethylbenzoyl)cyclohexane-1-carboxylic acid (CAS 1134295-57-0)
- 1-(Furan-2-yl)-2-((2-hydroxyethyl)amino)ethanone (CAS 1353956-65-6)
- Tert-butyl 2-cyano-8-azaspiro[4.5]Decane-8-carboxylate (CAS 2306272-99-9)
- N-(9-oxo-9H-fluoren-4-yl)acetamide (CAS 42135-35-3)
- (Asn5)-Delta-Sleep Inducing Peptide (H-2555.0005) (CAS 80064-67-1)
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