4-Chloro-2-(difluoromethoxy)-1-methylbenzene CAS 1261449-29-9
| CAS No. | 1261449-29-9 |
| Molecular Formula | C8H7ClF2O |
| Molecular Weight | 192.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 4-Chloro-2-(difluoromethoxy)-1-methylbenzene (CAS 1261449-29-9), a certified reference material (molecular formula C8H7ClF2O, MW 192.59 g/mol) for analytical method development and quality control.
The molecular framework of 4-Chloro-2-(difluoromethoxy)-1-methylbenzene (C8H7ClF2O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
CATO manufactures 4-Chloro-2-(difluoromethoxy)-1-methylbenzene under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H7ClF2O |
| Molecular Weight | 192.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- (3-Chloro-2,6-difluorobenzyl)hydrazine (CAS 1000805-99-1)
- (R)-2-Chloro-2,2-difluoro-1-phenylethan-1-ol (CAS 119454-39-6)
- 1-chloro-2-(difluoromethoxy)-4-methylbenzene (CAS 1225665-64-4)
- (S)-2-Chloro-2,2-difluoro-1-phenylethan-1-ol (CAS 124095-23-4)
- 4-Chloro-1-(difluoromethyl)-2-methoxybenzene (CAS 1261449-35-7)
- 2-Chloro-1-(difluoromethoxy)-4-methyl-benzene (CAS 1261554-69-1)
- 1-Chloro-2-(difluoromethoxy)-3-methylbenzene (CAS 1261567-06-9)
- 3-Chloro-4-(difluoromethyl)anisole (CAS 1261567-32-1)
Recommended Standards
- 2-(6-Chloropyridin-3-yl)-2,2-difluoroethan-1-amine (CAS 1204235-05-1)
- 2-(6-Chloropyridin-2-yl)-2,2-difluoroethan-1-amine (CAS 1204234-55-8)
- 2-(3-Chlorophenyl)-2,2-difluoroethan-1-ol (CAS 1195945-24-4)
- 1-(Chloromethyl)-2,5-difluoro-4-methoxybenzene (CAS 1261645-61-7)
- Isobutyraldehyde (CAS 78-84-2)
- Bis[4-(trifluoromethyl)phenyl]methanol (CAS 22543-52-8)
- 3,5-Dichloroisothiazole-4-carboxylic acid (CAS 3889-59-6)
- Octyl beta-D-Mannopyranoside (CAS 140147-38-2)
- 5-Cyclopropoxy-2-isopropoxypyridine (CAS 1243289-58-8)
- 1-(5-Chloro-2-fluorophenyl)ethan-1-ol (CAS 958653-04-8)
- 3,4,5-Trichlorobenzamide (CAS 99508-32-4)
- 1-(5-Phenylpyridin-3-yl)-1,4-diazepane (CAS 223796-38-1)
- Lithium 2-(1,3,4-oxadiazol-2-yl)acetate (CAS 1384428-46-9)
- Ac, Gastrin Releasing Peptide (20-27), porcine (CAS 77714-20-6)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com