1-(Difluoromethyl)-4-iodonaphthalene CAS 1261769-76-9
| CAS No. | 1261769-76-9 |
| Molecular Formula | C11H7F2I |
| Molecular Weight | 304.07 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-(Difluoromethyl)-4-iodonaphthalene (CAS 1261769-76-9), molecular formula C11H7F2I and molecular weight 304.07 g/mol, is a CATO reference standard with documented purity and traceability.
1-(Difluoromethyl)-4-iodonaphthalene (C11H7F2I) contains fluorine/iodine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H7F2I |
| Molecular Weight | 304.07 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/I-containing |
Related Difluoromethyl Standards
- 1-(Difluoromethyl)-2-iodonaphthalene (CAS 1261459-58-8)
- 2-(Difluoromethyl)-4-iodonaphthalene (CAS 1261459-62-4)
- 2-(Difluoromethyl)-5-iodonaphthalene (CAS 1261470-13-6)
- 1-(Difluoromethyl)-6-iodonaphthalene (CAS 1261532-79-9)
- 1-(Difluoromethyl)-5-iodonaphthalene (CAS 1261587-65-8)
- 2-(Difluoromethyl)-8-iodonaphthalene (CAS 1261660-99-4)
- 1-(Difluoromethyl)-3-iodonaphthalene (CAS 1261676-56-5)
- 2-(Difluoromethyl)-3-iodonaphthalene (CAS 1261807-76-4)
Recommended Standards
- 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(trifluoromethoxy)phenol (CAS 1350989-48-8)
- 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-(2,2,2-trifluoroethoxy)pyrimidine (CAS 1351234-12-2)
- 5-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-(trifluoromethoxy)pyridin-2-amine (CAS 1620575-08-7)
- 3-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethoxy)phenol (CAS 1689502-03-1)
- 1-(4-Ethylcyclohexyl)-N-methylmethanamine (CAS 1179599-73-5)
- Thiamine disulfide (dinitrate) (CAS 109125-52-2)
- Methyl 4-((2-aminophenyl)amino)-2,5-dihydrothiophene-3-carboxylate (CAS 61325-23-3)
- 6-Amino-5-(trifluoromethyl)nicotinonitrile (CAS 1256822-05-5)
- N-(2-(Benzofuran-3-yl)ethyl)-2-iodobenzamide (CAS 920537-55-9)
- Cefoperazone Impurity N8 (CAS 1416704-15-8)
- 2-Phenyloxazol-5(4H)-one (CAS 1199-01-5)
- 1-(4-Bromophenyl)-3-(4-fluorophenyl)propan-1-one (CAS 875433-11-7)
- 2-Methyl-1-(2-(methylthio)phenyl)propan-1-one (CAS 1432037-01-8)
- Semaglutide impurity 84 (CAS CATO-C4X-222684)
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