1-Chloro-2,5-difluoro-4-methoxybenzene CAS 1261846-22-3
| CAS No. | 1261846-22-3 |
| Molecular Formula | C7H5ClF2O |
| Molecular Weight | 178.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1-Chloro-2,5-difluoro-4-methoxybenzene (CAS 1261846-22-3), molecular formula C7H5ClF2O and molecular weight 178.56 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-Chloro-2,5-difluoro-4-methoxybenzene (C7H5ClF2O) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), 1-Chloro-2,5-difluoro-4-methoxybenzene meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C7H5ClF2O |
| Molecular Weight | 178.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-Chloro-2-(difluoromethoxy)benzene (CAS 119558-77-9)
- 1-Chloro-3-(difluoromethoxy)benzene (CAS 1214350-86-3)
- (3-Chloro-4,5-difluorophenyl)methanol (CAS 1260790-50-8)
- 2-Chloro-6-(difluoromethyl)phenol (CAS 1261440-82-7)
- 2-Chloro-1,3-difluoro-4-methoxybenzene (CAS 1261472-07-4)
- 3-Chloro-2-(difluoromethyl)phenol (CAS 1261479-57-5)
- 1-Chloro-4,5-difluoro-2-methoxybenzene (CAS 1261598-22-4)
- 1-Chloro-2,4-difluoro-5-methoxybenzene (CAS 1261628-93-6)
Recommended Standards
- 2-Chloro-4-(difluoromethyl)phenol (CAS 1261821-37-7)
- 1-Chloro-3,4-difluoro-2-methoxybenzene (CAS 1373921-04-0)
- 1-Chloro-2,3-difluoro-4-methoxybenzene (CAS 1261808-32-5)
- 4-Chloro-3,5-difluorobenzenemethanol (CAS 1431329-58-6)
- 1,3-Bis(1,3-dimethyl-1h-pyrazol-4-yl)propane-1,3-dione (CAS 1006356-08-6)
- 4-Amino-4-(3-hydroxyoxetan-3-yl)-N-tritylbutanamide (CAS 2201584-14-5)
- tert-Butyl 2-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carboxylate (CAS 100501-57-3)
- 1-(3-Methyl-1-benzothiophen-2-yl)ethanone (CAS 18781-31-2)
- N-Cyclopentyl-3-methylbenzamide (CAS 349403-64-1)
- 2-(5-Bromo-3,3-dimethyl-2-oxoindolin-1-yl)acetic acid (CAS 1263213-64-4)
- D10-1,2-Dimethoxyethane (CAS 107975-86-0)
- 1-((5-Chlorothiophen-2-yl)sulfonyl)-4-(thiophen-2-yl)piperidine (CAS 1396815-45-4)
- cis-3,5-Dimethylpiperidine (CAS 14446-75-4)
- Semaglutide impurity 29 (CAS 110990-08-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com