3'-Chloro-5'-fluoro-[1,1'-biphenyl]-3-ol CAS 1261894-07-8
| CAS No. | 1261894-07-8 |
| Molecular Formula | C12H8ClFO |
| Molecular Weight | 222.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3'-Chloro-5'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261894-07-8) is a high-purity analytical reference standard with the molecular formula C12H8ClFO and a molecular weight of 222.64 g/mol.
The molecular framework of 3'-Chloro-5'-fluoro-[1,1'-biphenyl]-3-ol (C12H8ClFO) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8ClFO |
| Molecular Weight | 222.64 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 3-Chloro-3'-fluoro-[1,1'-biphenyl]-4-ol (CAS 1214360-51-6)
- 4-Chloro-4'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1214360-53-8)
- 4-Chloro-2'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1214379-85-7)
- 2-(3-Chloro-4-fluorophenyl)phenol (CAS 1261889-68-2)
- 5-Chloro-4'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261897-12-4)
- 3'-Chloro-4'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261943-34-3)
- 5-Chloro-2'-fluoro-[1,1'-biphenyl]-3-ol (CAS 1261969-58-7)
- 4-(3-Chloro-5-fluorophenyl)phenol (CAS 1262001-95-5)
Recommended Standards
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- 4-(4-Chlorophenyl)-2-fluorophenol (CAS 1261944-84-6)
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- Tert-butyl (1S,2S,5R)-2-(((tert-butyldimethylsilyl)oxy)methyl)-4-oxo-3-azabicyclo[3.1.0]Hexane-3-carboxylate (CAS 220623-07-4)
- 2-(1-methyl-5-oxo-4H-pyrazol-3-yl)acetic acid (CAS 1094269-98-3)
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