2'-Chloro-6-fluoro-4'-methyl-[1,1'-biphenyl]-3-carboxylic acid CAS 1261978-73-7
| CAS No. | 1261978-73-7 |
| Molecular Formula | C14H10ClFO2 |
| Molecular Weight | 264.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2'-Chloro-6-fluoro-4'-methyl-[1,1'-biphenyl]-3-carboxylic acid (CAS 1261978-73-7), molecular formula C14H10ClFO2 and molecular weight 264.68 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2'-Chloro-6-fluoro-4'-methyl-[1,1'-biphenyl]-3-carboxylic acid (C14H10ClFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, a polycyclic aromatic system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H10ClFO2 |
| Molecular Weight | 264.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Chloro Standards
- 1-[2-chloro-4-(4-fluorophenoxy)phenyl]ethan-1-one (CAS 1021187-74-5)
- 2-Chloro-3-methoxy-4-(methylsulfonyl)benzoic acid (CAS 105917-83-7)
- 5-Chloro-2-fluoro-N-(4-methylpyridin-2-yl)benzamide (CAS 1089554-81-3)
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- 3-Chloro-3'-fluoro-4'-methyl-[1,1'-biphenyl]-4-carboxylic acid (CAS 1261893-13-3)
- 3'-Chloro-3-fluoro-4'-methyl-[1,1'-biphenyl]-4-carboxylic acid (CAS 1261901-57-8)
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Recommended Standards
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