5-(2-Fluoro-3-(trifluoromethyl)phenyl)pyrimidine-2,4-diol CAS 1261980-08-8
| CAS No. | 1261980-08-8 |
| Molecular Formula | C11H6F4N2O2 |
| Molecular Weight | 274.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 5-(2-Fluoro-3-(trifluoromethyl)phenyl)pyrimidine-2,4-diol is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
5-(2-Fluoro-3-(trifluoromethyl)phenyl)pyrimidine-2,4-diol (CAS 1261980-08-8) is a high-purity analytical reference standard with the molecular formula C11H6F4N2O2 and a molecular weight of 274.17 g/mol.
5-(2-Fluoro-3-(trifluoromethyl)phenyl)pyrimidine-2,4-diol (C11H6F4N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 5-(2-Fluoro-3-(trifluoromethyl)phenyl)pyrimidine-2,4-diol under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C11H6F4N2O2 |
| Molecular Weight | 274.17 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluoro Standards
- Methyl (2-fluoro-4,6-dinitrophenoxy)acetate (CAS 1206087-01-5)
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- 2-Fluoro-4-methoxyphenyl trifluoromethanesulphonate (CAS 550998-23-7)
- 3-(3-Fluoro-5-(trifluoromethyl)benzyl)-1-methyl-1h-pyrazol-5-ol (CAS 1358573-35-9)
- 2-Fluoro-3-(4-(trifluoromethyl)phenyl)bicyclo[1.1.1]pentane-1-carboxylic acid (CAS 2731010-62-9)
- 4-Fluoro-N-(5-(isoxazol-5-yl)-1,3,4-oxadiazol-2-yl)benzamide (CAS 946312-46-5)
- 1-(2-Fluoro-4,6-bis(trifluoromethyl)phenyl)ethan-1-one (CAS 1017778-58-3)
- 2-Fluoro-5-(3-methoxycarbonylphenyl)benzoic acid (CAS 1261912-57-5)
Recommended Standards
- 2-(Pyrrolidin-1-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1259445-03-8)
- N-Cyclobutyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-amine (CAS 1315350-34-5)
- 1-Methyl-1,2,3,4-tetrahydroquinoxaline-6-boronic Acid Pinacol Ester (CAS 1235141-88-4)
- 2-(Azetidin-1-yl)-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (CAS 1352135-90-0)
- Ethyl 2-(azepan-1-yl)-5-chlorothiazole-4-carboxylate (CAS 1403568-12-6)
- 3-(5-bromo-4-methyl-1,3-thiazol-2-yl)pyridine (CAS 1204608-91-2)
- 2,5-Dichloro-3-methylbenzenesulfonamide (CAS 1803812-69-2)
- 5-(1-Butylpiperidin-2-yl)pyridine-2(1H)-thione (CAS 1352528-40-5)
- (4-(1H-imidazol-2-yl)phenyl)boronic acid (CAS 1040848-01-8)
- [4-(piperidine-1-sulfonyl)phenyl]methanamine hydrochloride (CAS 1171923-10-6)
- 2-(2-Bromo-4-cyano-6-methoxyphenyl)acetic acid (CAS 1805414-20-3)
- 2-(5-Amino-1H-[1,2,4]triazol-3-yl)-1-phenyl-ethanone (CAS 95095-69-5)
- 4-(Bromomethyl)-1H-indazole Hydrobromide (CAS 264276-18-8)
- Palmitoyl Hexapeptide-12 (CAS 171263-26-6)
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