(E)-3-(2-methyl-5-(trifluoromethoxy)phenyl)acrylic acid CAS 1262019-25-9
| CAS No. | 1262019-25-9 |
| Molecular Formula | C11H9F3O3 |
| Molecular Weight | 246.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(E)-3-(2-methyl-5-(trifluoromethoxy)phenyl)acrylic acid (CAS 1262019-25-9), molecular formula C11H9F3O3 and molecular weight 246.18 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (E)-3-(2-methyl-5-(trifluoromethoxy)phenyl)acrylic acid (C11H9F3O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a certified reference material (CRM), (E)-3-(2-methyl-5-(trifluoromethoxy)phenyl)acrylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H9F3O3 |
| Molecular Weight | 246.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Recommended Standards
- Ethyl 3-oxo-3-(3,4,5-trifluorophenyl)propanoate (CAS 1260827-62-0)
- 3-[3-methyl-4-(trifluoromethoxy)phenyl]prop-2-enoic acid (CAS 1262019-38-4)
- 1-[3-(trifluoromethoxy)phenyl]cyclopropane-1-carboxylic acid (CAS 1260741-41-0)
- 2-(1,3-Dioxolan-2-yl)-1-(3,4,5-trifluorophenyl)ethan-1-one (CAS 1263365-50-9)
- 6,8-Dichloro-2-(pyridin-3-yl)quinoline-4-carboxylic acid (CAS 67059-24-9)
- Hydroxy-PEG3-acid (CAS 518044-49-0)
- H-Phe-Pro-βNA (CAS 76122-99-1)
- 1-(3,4-Dichlorobenzyl)-N-methylpiperidin-4-amine (CAS 328084-04-4)
- 4-oxa-1,10-diazatricyclo[7.3.1.0⁵¹³]tridecane (CAS 1432792-51-2)
- 2,3-Dimethyl-5-(2-methylbutyl)pyrazine (CAS 75492-01-2)
- (2E)-3-(2H-1,3-Benzodioxol-5-yl)-N-(3,4-dimethylphenyl)prop-2-enamide (CAS 300825-67-6)
- Carbonyltris(triphenylphosphine)palladium (CAS 24670-32-4)
- N-Phenyl-2-(p-tolyl)acetamide (CAS 3245-27-0)
- Insulin Degludec Impurity 18 (CAS CATO-C4X-215718)
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