2-Fluoro-5-methoxy-3-(trifluoromethyl)aniline CAS 1262198-05-9
| CAS No. | 1262198-05-9 |
| Molecular Formula | C8H7F4NO |
| Molecular Weight | 209.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Fluoro-5-methoxy-3-(trifluoromethyl)aniline (C8H7F4NO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
2-Fluoro-5-methoxy-3-(trifluoromethyl)aniline (CAS 1262198-05-9) is a high-purity analytical reference standard with the molecular formula C8H7F4NO and a molecular weight of 209.14 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Fluoro-5-methoxy-3-(trifluoromethyl)aniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H7F4NO |
| Molecular Weight | 209.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
- (5-Fluoro-2-(trifluoromethoxy)phenyl)methanamine (CAS 1092460-98-4)
- 1-(2-fluoro-5-nitrophenyl)-1H-tetrazole (CAS 1114822-66-0)
- (2-Fluoro-3-(trifluoromethoxy)phenyl)methanamine (CAS 1159512-65-8)
- 5-(2-Fluoro-4-nitrophenyl)-2H-tetrazole (CAS 1171930-23-6)
- 5-(2-Fluoro-5-nitrophenyl)-2H-tetrazole (CAS 1171938-74-1)
- 4-Fluoro-3-[(2,2,2-trifluoroethyl)amino]phenol (CAS 1228996-51-7)
- (2-Fluoro-4-(trifluoromethoxy)phenyl)methanamine (CAS 1240257-11-7)
- (4-Fluoro-2-(trifluoromethoxy)phenyl)methanamine (CAS 1241828-99-8)
Recommended Standards
- 2-Fluoro-4-(2,2,2-trifluoroethoxy)aniline (CAS 1248331-97-6)
- Cgp 37849 (CAS 127910-31-0)
- 2-Fluoro-5-(2,2,2-trifluoroethoxy)aniline (CAS 1245823-39-5)
- 4-(2,2-Difluoroethoxy)-2,5-difluoroaniline (CAS 1342229-28-0)
- 1-[(1-aminobutan-2-yl)oxy]-2-(trifluoromethyl)benzene hydrochloride (CAS 1384430-04-9)
- (R)-2-(tert-butoxycarbonyl)-9-formyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid (CAS 327603-49-6)
- 2,2,2-Trifluoro-1-(4-(methylamino)phenyl)ethanone (CAS 75822-12-7)
- Rivaroxaban Impurity 31 (CAS 1424944-35-3)
- 3-(Difluoromethyl)-5-methylpyridine-2,6-diamine (CAS 1806806-10-9)
- 2-(Difluoromethyl)thiophene (CAS 98909-14-9)
- Methyl 5-(chlorosulfonyl)-3-methyl-1h-pyrazole-4-carboxylate (CAS 1346270-23-2)
- (R)-(5-Oxopyrrolidin-2-yl)methyl 4-Methylbenzenesulfonate (CAS 128899-31-0)
- Decyl isocyanate (CAS 1191-69-1)
- Tetrapeptide-3 (CAS 827306-97-8)
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