4-([1,1'-Biphenyl]-4-yl)-2-chloroquinazoline CAS 1262866-93-2
| CAS No. | 1262866-93-2 |
| Molecular Formula | C20H13ClN2 |
| Molecular Weight | 316.78 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-([1,1'-Biphenyl]-4-yl)-2-chloroquinazoline (CAS 1262866-93-2), molecular formula C20H13ClN2 and molecular weight 316.78 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-([1,1'-Biphenyl]-4-yl)-2-chloroquinazoline (C20H13ClN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), 4-([1,1'-Biphenyl]-4-yl)-2-chloroquinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H13ClN2 |
| Molecular Weight | 316.78 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 15.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Biphenyl Standards
- 4-([1,1'-Biphenyl]-3-yl)-2-chloroquinazoline (CAS 1413365-66-8)
- 2-([1,1'-Biphenyl]-3-yl)-3-chloroquinoxaline (CAS 2331183-37-8)
- 2-[1,1′-Biphenyl]-4-yl-4-chloroquinazoline (CAS 94546-58-4)
- 3-{[1,1'-Biphenyl]-4-yl}-6-(piperazin-1-yl)pyridazine (CAS 1354940-29-6)
- 4-([1,1'-Biphenyl]-4-yl)-5-(methylsulfonyl)-1,2,3-thiadiazole (CAS 1708259-44-2)
- N-([1,1'-biphenyl]-2-yl)-2-(benzylamino)acetamide (CAS 333341-34-7)
- 5-([1,1'-Biphenyl]-4-yloxy)isobenzofuran-1,3-dione (CAS 122590-11-8)
- 4-(Biphenyl-4-yl)-DL-phenylalanine (CAS 1946843-02-2)
Recommended Standards
- 1241675-01-3 2-{[(3-Chloro-2-methylphenyl)amino]methyl}-3a,4,7,7a-tetrahydro-1H-4,7-methanoisoindole-1,3-dione MFCD17069389 (CAS 1241675-01-3)
- Ribociclib Impurity 27 (CAS 1298101-40-2)
- Tert-butyl ((2-chloro-3-(dimethoxymethyl)pyridin-4-yl)methyl)carbamate (CAS 1186310-71-3)
- 7-Chloro-4-(4-(dimethylamino)phenyl)-4,5-dihydrobenzo[f][1,4]oxazepin-3(2H)-one (CAS 1326844-94-3)
- 1-((4-Bromobenzyl)oxy)-3-fluorobenzene (CAS 1249539-73-8)
- Furosemide Impurity 1 HCl (Furfurylamine HCl) (CAS 4753-68-8)
- 3-(4-Nitrobenzyl)piperazin-2-one (CAS 1246548-53-7)
- 2-((4-(sec-Butyl)phenyl)amino)nicotinic acid (CAS 1206107-15-4)
- Fuchsin S calcium salt (CAS 136132-76-8)
- 2'-(Difluoromethoxy)-3'-hydroxypropiophenone (CAS 1261604-79-8)
- Cariprazine Impurity 65 (CAS CATO-C4X-240865)
- 2-(3-Aminophenyl)phenol (CAS 161887-01-0)
- 2-(2-Methylpiperidin-1-yl)nicotinonitrile (CAS 945347-49-9)
- Tirzepatide-d7 Ditrifluoroacetate (CAS CATO-CPTD788698)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com