(1 <I> R </I> ,8 <I> S </I> ,9 <I> S </I>)-bicyclo\ [6.1.0] non-4-yn-9-ylmethanol CAS 1263166-90-0

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (1 <I> R </I> ,8 <I> S </I> ,9 <I> S </I>)-bicyclo\ [6.1.0] non-4-yn-9-ylmethanol.

(1 <I> R </I> ,8 <I> S </I> ,9 <I> S </I>)-bicyclo\ [6.1.0] non-4-yn-9-ylmethanol (CAS 1263166-90-0), molecular formula C10H14O and molecular weight 150.22 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of (1 <I> R </I> ,8 <I> S </I> ,9 <I> S </I>)-bicyclo\ [6.1.0] non-4-yn-9-ylmethanol (C10H14O) is characterized by a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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