4,4-Difluoro-1-cyclohexanecarboxylic anhydride CAS 1263377-47-4
| CAS No. | 1263377-47-4 |
| Molecular Formula | C14H18F4O3 |
| Molecular Weight | 310.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4,4-Difluoro-1-cyclohexanecarboxylic anhydride.
4,4-Difluoro-1-cyclohexanecarboxylic anhydride (CAS 1263377-47-4), molecular formula C14H18F4O3 and molecular weight 310.28 g/mol, is a CATO reference standard with documented purity and traceability.
4,4-Difluoro-1-cyclohexanecarboxylic anhydride (C14H18F4O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 4,4-Difluoro-1-cyclohexanecarboxylic anhydride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C14H18F4O3 |
| Molecular Weight | 310.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
Related Difluoro Standards
- beta-(4,4-Difluoro-1-piperidinyl)-2-(trifluoromethyl)-5-pyrimidineethanamine (CAS 1192569-99-5)
- 1-(3,5-Difluoro-4-(hexyloxy)phenyl)-2,2,2-trifluoroethanone (CAS 1443305-28-9)
- 2,7-Difluoro-9H-fluorene (CAS 2195-50-8)
- (R)-4,4-difluoro-2-methyl-1-(4-nitro-3-(trifluoromethyl)phenyl)pyrrolidine (CAS 1236061-16-7)
- Benzyl 6,6-difluoro-2,8-diazaspiro[4.5]Decane-8-carboxylate (CAS 1896750-71-2)
- 4,5-Difluoro-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine (CAS 685513-89-7)
- 2,2-difluoro-2-[1,1,2,2-tetrafluoro-2-(trifluoromethoxy)ethoxy]acetic acid methyl ester 39187-41-2 A824447 methyl 2,2-bis(fluoranyl)-2-[1,1,2,2-tetrakis(fluoranyl)-2-(trifluoromethyloxy)ethoxy]ethanoate (CAS 39187-41-2)
- 5,8-Difluoro-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-boronic Acid Pinacol Ester (CAS 1221502-87-9)
Recommended Standards
- 1171917-21-7 3-{[2-(4-Fluorophenyl)pyrimidin-4-yl]oxy}benzoic acid MFCD14281602 (CAS 1171917-21-7)
- (3-(Benzyloxy)phenyl)pentafluoro-lambda6-sulfane (CAS 1272542-25-2)
- 3-{[6-(4-Fluorophenyl)pyrimidin-4-yl]oxy}benzoic acid (CAS 1171894-01-1)
- N-(3,4-difluorophenyl)-[1,2,4]triazolo[4,3-a]pyridine-8-sulfonamide (CAS 1291486-52-6)
- (4-(6-Aminopyrazin-2-yl)phenyl)methanol (CAS 1365969-34-1)
- 5-Chloro-6-fluoropyrazin-2-amine (CAS 2858665-15-1)
- 2-Amino-6-(difluoromethyl)pyridine-3,5-diol (CAS 1806911-83-0)
- 2-Chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide (CAS 371219-74-8)
- 3-(2-Methyl-4-nitro-1H-imidazol-1-yl)propane-1,2-diol (CAS 5313-40-6)
- 4-(Di(1H-indol-3-yl)methyl)phenol (CAS 151358-47-3)
- 1-(5-Chloropyridin-2-yl)ethanol (CAS 71777-68-9)
- tert-Butyl 3-[(2-phenylethyl)amino]propanoate (CAS 175071-98-4)
- N-(2,2-dimethylthietan-3-yl)cyclobutanecarboxamide (CAS 1871975-67-5)
- Semaglutide impurity 86 (CAS CATO-C4X-152686)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com