Paricalcitol Impurity 12 CAS 1263504-45-5
| CAS No. | 1263504-45-5 |
| Molecular Formula | C20H27O3P |
| Molecular Weight | 346.40 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Paricalcitol Impurity 12 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
CATO supplies Paricalcitol Impurity 12 (CAS 1263504-45-5), a pharmacopoeial impurity reference standard (molecular formula C20H27O3P, MW 346.40 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Paricalcitol Impurity 12 (C20H27O3P) is characterized by a steroid core, a phosphonate group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C20H27O3P |
| Molecular Weight | 346.40 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
Related Paricalcitol Standards
- Paricalcitol Impurity 10 (CAS CATO-C4X-138710)
- Paricalcitol Impurity 15 (CAS 100858-25-1)
- Paricalcitol Impurity 16 (CAS 100858-26-2)
- Paricalcitol Impurity 27 (CAS 139356-35-7)
- Paricalcitol Impurity 20 (CAS 342645-83-4)
- Paricalcitol Impurity 11 (CAS 95716-69-1)
- Paricalcitol Impurity 32 (CAS 63819-60-3)
- Paricalcitol Impurity 34 (CAS 1715-86-2)
Recommended Standards
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com