2,3,5,6-Tetramethylpyrazine hydrochloride CAS 126400-81-5
| CAS No. | 126400-81-5 |
| Molecular Formula | C8H12N2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2,3,5,6-Tetramethylpyrazine hydrochloride is closely related to a nitrile group, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2,3,5,6-Tetramethylpyrazine hydrochloride (CAS 126400-81-5) is a high-purity analytical reference standard with the molecular formula C8H12N2HCl and a molecular weight of 172.66 g/mol.
The molecular framework of 2,3,5,6-Tetramethylpyrazine hydrochloride (C8H12N2HCl) is characterized by a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H12N2 HCl |
| Molecular Weight | 172.66 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Tetramethylpyrazine Standards
Recommended Standards
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- tert-Butyl 2-(10H-phenothiazin-10-yl)acetate (CAS 68825-29-6)
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- 4-chloro-2-[(phenylthio)methyl]-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine (CAS 128277-14-5)
- (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-((1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl)amino)butanoic acid 872169-32-9 (CAS 872169-32-9)
- Chlormethiazole hydrochloride, 98% (CAS 6001-74-7)
- 1-(2-Fluorophenyl)cyclobutan-1-ol (CAS 1539420-76-2)
- 1-((5-Chloro-3-methylbenzo[b]thiophen-2-yl)sulfonyl)-4-(2-hydroxyethyl)-5-methyl-1,2-dihydro-3H-pyrazol-3-one (CAS 861207-40-1)
- Glucagon (1-29) (CAS 16941-32-5)
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