tert-Butyl 6,6-difluoro-2-azaspiro[3.3]heptane-2-carboxylate CAS 1264635-66-6
| CAS No. | 1264635-66-6 |
| Molecular Formula | C11H17F2NO2 |
| Molecular Weight | 233.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
tert-Butyl 6,6-difluoro-2-azaspiro[3.3]heptane-2-carboxylate (CAS 1264635-66-6), molecular formula C11H17F2NO2 and molecular weight 233.25 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of tert-Butyl 6,6-difluoro-2-azaspiro[3.3]heptane-2-carboxylate (C11H17F2NO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H17F2NO2 |
| Molecular Weight | 233.25 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 6-(3-Nitrophenyl)pyridazine-3(2H)-thione (CAS 1225715-73-0)
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- 3-(4-((Trifluoromethyl)thio)phenyl)prop-2-en-1-amine (CAS 1344799-85-4)
- 2-Amino-4-(bromomethyl)-6-(difluoromethyl)pyridin-3-ol (CAS 1806836-45-2)
- N-(4-Chloro-2-methylphenyl)-2-methoxybenzamide (CAS 449155-88-8)
- 2-(Furan-2-yl)-3,4-dihydropyrimidin-4-one (CAS 27110-98-1)
- Methyl 5-aminoisothiazole-3-carboxylate, 96% (CAS 1094070-51-5)
- (4,5-Dihydronaphtho[1,2-b]thiophen-2-yl)(morpholino)methanone (CAS 320424-00-8)
- 2-[(4-bromo-1H-pyrazol-1-yl)methyl]-1-(difluoromethyl)-1H-imidazole (CAS 1178659-97-6)
- 2,3-Dihydro-1,6-naphthyridin-4(1H)-one (CAS 1211528-58-3)
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- 1-Pyridin-4-yl-imidazolidin-2-one (CAS 1176419-87-6)
- Semaglutide impurity 46 (CAS CATO-C4X-222646)
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