Ethyl 2-((3-(trifluoromethyl)phenyl)amino)thiazole-4-carboxylate CAS 126533-82-2
| CAS No. | 126533-82-2 |
| Molecular Formula | C13H11F3N2O2S |
| Molecular Weight | 316.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Ethyl 2-((3-(trifluoromethyl)phenyl)amino)thiazole-4-carboxylate.
Ethyl 2-((3-(trifluoromethyl)phenyl)amino)thiazole-4-carboxylate (CAS 126533-82-2) is a high-purity analytical reference standard with the molecular formula C13H11F3N2O2S and a molecular weight of 316.30 g/mol.
The molecular framework of Ethyl 2-((3-(trifluoromethyl)phenyl)amino)thiazole-4-carboxylate (C13H11F3N2O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H11F3N2O2S |
| Molecular Weight | 316.30 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Ethyl Standards
- 2-{[4-(trifluoromethyl)-1,3-thiazol-2-yl]amino}-3,4,5,6,7,8-hexahydroquinazolin-4-one (CAS 865659-90-1)
- 3-((3-(Trifluoromethyl)benzyl)oxy)thiophene-2-carbohydrazide (CAS 343376-03-4)
- Ethyl 2-[4-(trifluoromethyl)anilino]-1,3-thiazole-4-carboxylate (CAS 860783-84-2)
- Methyl 3-((3-(trifluoromethyl)benzyl)oxy)thiophene-2-carboxylate (CAS 343375-98-4)
- Ethyl 2-(4-(((trifluoromethyl)sulfonyl)oxy)cyclohex-3-en-1-yl)acetate (CAS 1166829-72-6)
- Ethyl 2-(((trifluoromethyl)sulfonyl)oxy)cyclohept-1-enecarboxylate (CAS 144242-09-1)
- 2-(3-Oxo-1-(3-(trifluoromethyl)benzyl)piperazin-2-yl)acetic acid (CAS 1033600-26-8)
- 2-(4-(Trifluoromethyl)phenyl)quinoline-8-carboxamide (CAS 655222-46-1)
Recommended Standards
- 2,2,2-trifluoroethyl N-[3-(2-methyl-1,3-thiazol-4-yl)phenyl]carbamate (CAS 1221724-56-6)
- 2',5'-Difluoro-[1,1':4',1"-terphenyl]-4,4"-dicarbonitrile (CAS 1685285-13-5)
- (E)-Bis((S)-1-ethoxy-1-oxopropan-2-yl) fumarate (CAS 111293-23-3)
- Ethyl 4-methyl-2-(5-(trifluoromethyl)pyridin-2-yl)thiazole-5-carboxylate (CAS 175277-54-0)
- 1-Benzyl-4-chloro-1h-pyrazol-3-amine (CAS 895930-09-3)
- 2-Amino-5-phenylpyrimidine-4,6-diol (CAS 154146-07-3)
- 2-(2,4-Dichlorophenoxy)-N-(4-methoxyphenyl)propanamide (CAS 284488-00-2)
- Vericiguat Impurity 14 (CAS 2135333-04-7)
- N'-(2-Cyanoacetyl)benzohydrazide (CAS 16501-75-0)
- 1-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carbonyl chloride (CAS 175137-19-6)
- 1,3-Dibenzylpiperidin-4-one (CAS 188788-31-0)
- 5-((Tert-butoxycarbonyl)amino)-2,3-dimethylbenzoic acid (CAS 1343603-36-0)
- 5-(Methoxymethyl)spiro[2.3]hexane-5-carbonitrile (CAS 1707371-07-0)
- Semaglutide Impurity 4 (CAS CATO-C4X-22264)
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