2-(Chloromethyl)-1,3-difluoro-5-methylbenzene CAS 1266114-64-0
| CAS No. | 1266114-64-0 |
| Molecular Formula | C8H7ClF2 |
| Molecular Weight | 176.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-(Chloromethyl)-1,3-difluoro-5-methylbenzene is closely related to fluorine/chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-(Chloromethyl)-1,3-difluoro-5-methylbenzene (CAS 1266114-64-0), molecular formula C8H7ClF2 and molecular weight 176.59 g/mol, is a CATO reference standard with documented purity and traceability.
2-(Chloromethyl)-1,3-difluoro-5-methylbenzene (C8H7ClF2) contains fluorine/chlorine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-(Chloromethyl)-1,3-difluoro-5-methylbenzene under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H7ClF2 |
| Molecular Weight | 176.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
Related Chloromethyl Standards
- 1-(Chloromethyl)-2,3-difluoro-4-methylbenzene (CAS 1035574-30-1)
- 1-(chloromethyl)-3-(difluoromethyl)benzene (CAS 1169873-26-0)
- 1-(Chloromethyl)-2-(difluoromethyl)benzene (CAS 1182357-10-3)
- 1-(chloromethyl)-4-(difluoromethyl)benzene (CAS 1461706-37-5)
- 1-(CHLOROMETHYL)-2,5-DIFLUORO-4-METHYLBENZENE (CAS 1499128-34-5)
- 2-(Chloromethyl)-1,3-difluoro-4-methylbenzene (CAS 647037-11-4)
- 5-(Chloromethyl)-3-(2-methoxyethyl)-1,2,4-oxadiazole (CAS 1082766-40-2)
- 3-(chloromethyl)-5-(2-methoxyethyl)-1,2,4-oxadiazole (CAS 1250052-81-3)
Recommended Standards
- 3-Chloro-5-(difluoromethyl)toluene (CAS 1261821-41-3)
- 3-Chloro-4-(difluoromethyl)toluene (CAS 1261760-76-2)
- 5-Chloro-2-(difluoromethyl)toluene (CAS 1261729-10-5)
- 3,4-Difluoro-5-methylbenzyl chloride (CAS 1803785-10-5)
- (4Z)-2-[(2,4-Dichlorophenyl)methoxy]-4-(phenylmethylidene)-1,2,3,4-tetrahydroisoquinoline-1,3-dione (CAS 338396-49-9)
- Betrixaban Impurity 4 (CAS 280773-17-3)
- (R)-3-((R)-1-(6-bromopyridin-3-yl)ethyl)-3-methyl-1,3-dihydro-2H-pyrrolo[2,3-b]pyridin-2-one (CAS 2081858-95-7)
- 4-(Difluoromethyl)isoquinoline (CAS 862075-83-0)
- Methyl 3,6-dibromo-2-methoxy-1-naphthoate (CAS 1198475-39-6)
- 1-[4-(Benzyloxy)phenyl]-5-oxopyrrolidine-3-carboxylic acid (CAS 73422-90-9)
- (2E)-2-(4-Acetyl-5-methyl-1,3-thiazol-2-yl)-3-(3,4-dimethoxyphenyl)prop-2-enenitrile (CAS 478080-59-0)
- 2-(3-Bromopropyl)bicyclo[2.2.1]heptane (CAS 1559672-59-1)
- (R)-1-(3-(Tert-butyl)phenyl)ethan-1-amine (CAS 1213335-91-1)
- Semaglutide impurity 84 (CAS CATO-C4X-222684)
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