1-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole CAS 1269293-56-2
| CAS No. | 1269293-56-2 |
| Molecular Formula | C10H6ClF3N2 |
| Molecular Weight | 246.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
1-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole (CAS 1269293-56-2), molecular formula C10H6ClF3N2 and molecular weight 246.62 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole (C10H6ClF3N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H6ClF3N2 |
| Molecular Weight | 246.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chlorophenyl Standards
- 5-(3-Chlorophenyl)-3-(trifluoromethyl)-1H-pyrazole (CAS 1245619-64-0)
- 1-(2-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole (CAS 1269291-18-0)
- 1-(3-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole (CAS 1269292-85-4)
- 3-(4-Chlorophenyl)-5-(trifluoromethyl)-1H-pyrazole (CAS 142623-90-3)
- 2-(2-Chlorophenyl)-4-(trifluoromethyl)-1H-imidazole (CAS 33469-13-5)
- 2-(3-Chlorophenyl)-4-(trifluoromethyl)-1H-imidazole (CAS 33469-14-6)
- 2-(4-Chlorophenyl)-4-(trifluoromethyl)-1H-imidazole (CAS 33469-15-7)
- 1-(4-Chlorophenyl)-3,3-difluorocyclobutane-1-carboxylic acid (CAS 1190643-85-6)
Recommended Standards
- 2-Chloro-4-(trifluoromethyl)quinolin-7-amine (CAS 1416439-79-6)
- 4-Chloro-2-methyl-6-(trifluoromethyl)quinazoline (CAS 1422284-63-6)
- 4-(4-Chloro-3-fluoro-2-hydroxyphenyl)-4-oxobutanoic acid (CAS 1208265-79-5)
- 2-Chloro-8-(trifluoromethyl)quinolin-4-amine (CAS 1708160-46-6)
- 4-Bromo-N-[(4-chlorophenyl)methyl]aniline (CAS 195968-98-0)
- N-(5-((2-Amino-2-oxoethyl)thio)-1,3,4-thiadiazol-2-yl)-2-(trifluoromethyl)benzamide (CAS 868975-09-1)
- Methyl 4-(1-aminoethyl)benzoate hydrochloride (CAS 934388-45-1)
- n-Benzyl-2-phenyl-2-(piperazin-1-yl)acetamide hydrochloride (CAS 1803561-02-5)
- 6-(Difluoromethyl)-3-fluoro-2-methoxypyridin-4-amine (CAS 1806813-68-2)
- Elagolix Impurity 41 (CAS 56613-80-0)
- Benzyl 4-(2,5-dimethoxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 300689-94-5)
- 5-Bromo-3-(tert-butyl)-1-methyl-1H-pyrazole (CAS 1187968-59-7)
- 6,8-Dihydroxy-3-methylisochroman-1-one (CAS 19314-92-2)
- Semaglutide impurity 247 (CAS CATO-C4X-2226247)
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