Lansoprazole Impurity 8 CAS 127337-60-4
| CAS No. | 127337-60-4 |
| Molecular Formula | C9H9ClF3NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Lansoprazole Impurity 8 (C9H9ClF3NOHCl) contains an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Lansoprazole Impurity 8 (CAS 127337-60-4, C9H9ClF3NOHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H9ClF3NO HCl |
| Molecular Weight | 276.08 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Lansoprazole Standards
- Lansoprazole EP Impurity D (CAS 102976-62-5)
- Lansoprazole Impurity 37 (CAS 103312-62-5)
- Lansoprazole EP Impurity C/USP Impurity B (CAS 103577-40-8)
- Lansoprazole (CAS 103577-45-3)
- Lansoprazole Impurity 45 (CAS 103577-61-3)
- Lansoprazole Impurity 51 (CAS 103577-66-8)
- Lansoprazole Impurity 18 (CAS 1083100-26-8)
- Lansoprazole Impurity 10 (CAS 1083100-27-9)
Recommended Standards
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- Neuropeptide Y (2-36) (human, rat) trifluoroacetate salt (CAS 123139-39-9)
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