2-Chloro-5-methoxybenzonitrile CAS 127667-00-9
| CAS No. | 127667-00-9 |
| Molecular Formula | C8H6ClNO |
| Molecular Weight | 167.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-5-methoxybenzonitrile (CAS 127667-00-9) is a high-purity analytical reference standard with the molecular formula C8H6ClNO and a molecular weight of 167.59 g/mol.
2-Chloro-5-methoxybenzonitrile (C8H6ClNO) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2-Chloro-5-methoxybenzonitrile under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H6ClNO |
| Molecular Weight | 167.59 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-Chloro-4-methylbenzoxazole (CAS 1001185-81-4)
- 4-Chloro-2-methoxybenzonitrile (CAS 100960-68-7)
- 3-Chloro-4-methoxybenzonitrile (CAS 102151-33-7)
- 3-Chloro-5-(hydroxymethyl)benzonitrile (CAS 1021871-35-1)
- 3-Chloro-5-methoxyphenylisocyanide (CAS 1029634-54-5)
- 4-Chloro-3-(hydroxymethyl)benzonitrile (CAS 105191-40-0)
- 2-Chloro-6,7-dihydro-5H-cyclopenta[b]pyridin-5-one (CAS 1092301-56-8)
- 2-Chloro-5H-cyclopenta[b]pyridin-7(6H)-one (CAS 1150617-92-7)
Recommended Standards
- 2-Chloro-4-methoxybenzonitrile (CAS 127666-99-3)
- 3-Chloro-7-methylbenzo[d]isoxazole (CAS 128520-86-5)
- 7-Chloro-2-methylbenzoxazole (CAS 126892-02-2)
- 6-(Chloromethyl)benzo[d]oxazole (CAS 1314982-48-3)
- 2-Bromo-6-(trifluoromethoxy)pyridine (CAS 1221172-10-6)
- 3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carboxylic acid (CAS 337463-89-5)
- 5-Methyl-6-morpholinopyrimidine-2,4(1H,3H)-dione (CAS 202916-71-0)
- Boc-Dap-NE (CAS 160800-65-7)
- N-(2,4-Dichlorobenzyl)-N-(3-nitrophenyl)acetamide (CAS 1119450-66-6)
- 2-Amino-1-(3-ethoxy-2,3-dioxopropyl)pyridin-1-ium bromide (CAS 832099-51-1)
- Amodiaquine Dihydrochloride Dihydrate (CAS 6398-98-7)
- (R)-tert-Butyl (1-(2-aminoacetyl)pyrrolidin-3-yl)(cyclopropyl)carbamate (CAS 1354015-45-4)
- 2-(1-Cyclohexylpiperazin-2-yl)ethan-1-ol (CAS 1211505-12-2)
- Glucagon Monohydrochloride (CAS 28270-04-4)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com