tert-Butyl (2S)-2-(bromomethyl)-4,4-difluoropyrrolidine-1-carboxylate CAS 1279894-15-3
| CAS No. | 1279894-15-3 |
| Molecular Formula | C10H16BrF2NO2 |
| Molecular Weight | 300.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including tert-Butyl (2S)-2-(bromomethyl)-4,4-difluoropyrrolidine-1-carboxylate.
tert-Butyl (2S)-2-(bromomethyl)-4,4-difluoropyrrolidine-1-carboxylate (CAS 1279894-15-3), molecular formula C10H16BrF2NO2 and molecular weight 300.14 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of tert-Butyl (2S)-2-(bromomethyl)-4,4-difluoropyrrolidine-1-carboxylate (C10H16BrF2NO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H16BrF2NO2 |
| Molecular Weight | 300.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- Ethyl 5-amino-1-(3,4-dichlorophenyl)-1H-pyrazole-3-carboxylate (CAS 1264043-82-4)
- Ethyl 5-amino-1-(2,3-dichlorophenyl)pyrazole-4-carboxylate (CAS 1285132-66-2)
- Ethyl 5-amino-1-(2,5-dichlorophenyl)-1H-pyrazole-4-carboxylate (CAS 1264041-82-8)
- 2-tert-Butyl-3-Iodoimidazo[1,2-a]pyridine (CAS 1426142-81-5)
- 2-[3-(5-Bromo-6-methoxynaphthalen-2-yl)-4-methyl-1H-pyrazol-1-yl]-3-chloro-5-(trifluoromethyl)pyridine (CAS 318239-45-1)
- 1-Benzyl-2-(4-methoxyphenyl)-6-oxopiperidine-3-carboxylic acid (CAS 937604-06-3)
- (4-Hydroxypiperidin-1-yl)(pyrazin-2-yl)methanone hydrochloride (CAS 1185309-12-9)
- (4S)-4,5-Dihydro-2,4,5,5-tetraphenyloxazole (CAS 2271168-31-9)
- 2-(Chloromethyl)-4-(4-nitrophenyl)thiazole (CAS 89250-26-0)
- 3-(3-Aminopropoxy)propane-1,2-diol (CAS 139755-70-7)
- cis-Diaquodiammineplatinum(II) dinitrate (CAS 13601-02-0)
- S-butyl ethanethioate (CAS 928-47-2)
- 5-Chloro-2-fluoro-4-(trifluoromethyl)benzoyl chloride (CAS 2383814-44-4)
- Acetyl Tetrapeptide-5 (CAS 820959-17-9)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com