Methyl 2-hydroxy-3-iodobenzoate CAS 128033-28-3
| CAS No. | 128033-28-3 |
| Molecular Formula | C8H7IO3 |
| Molecular Weight | 278.04 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 2-hydroxy-3-iodobenzoate.
Methyl 2-hydroxy-3-iodobenzoate (CAS 128033-28-3) is a high-purity analytical reference standard with the molecular formula C8H7IO3 and a molecular weight of 278.04 g/mol.
The molecular framework of Methyl 2-hydroxy-3-iodobenzoate (C8H7IO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H7IO3 |
| Molecular Weight | 278.04 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | I-containing |
Related Methyl Standards
- 4-Hydroxy-3-iodo-5-methylbenzoic acid (CAS 1195666-68-2)
- 3-Hydroxy-2-iodo-4-methoxybenzaldehyde (CAS 138490-94-5)
- 2-(3-Hydroxy-5-iodophenyl)acetic acid (CAS 1393540-48-1)
- Methyl 4-Hydroxy-3-iodobenzoate (CAS 15126-06-4)
- 2-Hydroxy-3-iodo-4-methoxybenzaldehyde (CAS 155560-24-0)
- Methyl 3-Hydroxy-4-iodobenzoate (CAS 157942-12-6)
- 5-Hydroxy-2-iodo-4-methylbenzoic acid (CAS 1643953-27-8)
- Methyl 3-hydroxy-2-iodobenzoate (CAS 1823056-63-8)
Recommended Standards
- 5-(Hydroxymethyl)-2-iodobenzoic acid (CAS 1187238-27-2)
- 3-(Hydroxymethyl)-4-iodobenzoic acid (CAS 1187238-25-0)
- 3-(Hydroxymethyl)-2-iodobenzoic acid (CAS 1187238-23-8)
- Methyl 2-Bromo-5-fluoro-3-nitrobenzoate (CAS 328547-12-2)
- ethyl 6-oxo-1,7-dihydropyrazolo[3,4-b]pyridine-5-carboxylate (CAS 2106705-88-6)
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