3-(Thiophen-2-yl)-5-(trifluoromethyl)-1H-pyrazole CAS 128228-96-6

Purity 97%+In StockPharmaceutical Standards
CAS No.128228-96-6
Molecular FormulaC8H5F3N2S
Molecular Weight218.20 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

3-(Thiophen-2-yl)-5-(trifluoromethyl)-1H-pyrazole CAS 128228-96-6 chemical structure

Description

The occurrence of 3-(Thiophen-2-yl)-5-(trifluoromethyl)-1H-pyrazole is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

3-(Thiophen-2-yl)-5-(trifluoromethyl)-1H-pyrazole (CAS 128228-96-6) is a high-purity analytical reference standard with the molecular formula C8H5F3N2S and a molecular weight of 218.20 g/mol.

The molecular framework of 3-(Thiophen-2-yl)-5-(trifluoromethyl)-1H-pyrazole (C8H5F3N2S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 3-(Thiophen-2-yl)-5-(trifluoromethyl)-1H-pyrazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC8H5F3N2S
Molecular Weight218.20 g/mol
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1993
Halogen ContentF-containing
Nitrogen Atoms2
Sulfur Atoms1

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