(E)-2-Cyano-3-(dimethylamino)-N-(3-methoxyphenyl)-2-propenamide CAS 128259-57-4
| CAS No. | 128259-57-4 |
| Molecular Formula | C13H15N3O2 |
| Molecular Weight | 245.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(E)-2-Cyano-3-(dimethylamino)-N-(3-methoxyphenyl)-2-propenamide (CAS 128259-57-4), molecular formula C13H15N3O2 and molecular weight 245.28 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (E)-2-Cyano-3-(dimethylamino)-N-(3-methoxyphenyl)-2-propenamide (C13H15N3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H15N3O2 |
| Molecular Weight | 245.28 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 3 |
Related E Standards
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Recommended Standards
- N-(4-((1H-1,2,4-triazol-1-yl)methyl)phenyl)-2-(methylamino)acetamide (CAS 1282115-36-9)
- 2-((6-(4-Methoxyphenyl)pyridazin-3-yl)oxy)ethan-1-amine (CAS 1283109-50-1)
- Methyl 1-(2-cyanopyridin-4-yl)piperidine-4-carboxylate (CAS 1283441-69-9)
- 1-(4-methylpyridin-2-yl)-5-propyl-1H-pyrazole-4-carboxylic acid (CAS 1284400-70-9)
- Methyl 4-amino-3-(imidazo[1,2-a]pyridin-2-yl)butanoate (CAS 1496929-67-9)
- Ethyl 2-(4-formylbenzamido)acetate (CAS 1987453-37-1)
- Ethyl 4-hydrazinyl-2-methylbenzoate (CAS 1208351-24-9)
- Amino-naphthalen-1-yl-acetic acid (CAS 97611-60-4)
- 6-(2,2,2-Trifluoroethoxy)-3-pyridinamine (CAS 72617-82-4)
- 3-(trifluoromethyl)-7,8,9,10-tetrahydro-5H-pyrido[1,2-a]quinoxalin-6(6aH)-one (CAS 1009240-54-3)
- 4-(2-(4-Chlorophenyl)acetyl)-N-(pyridin-3-ylmethyl)-1H-pyrrole-2-carboxamide (CAS 478040-33-4)
- n-(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1h-pyrazol-4-yl)-4-nitrobenzenesulfonamide (CAS 301332-17-2)
- Methyl 5-(aminomethyl)thiophene-2-carboxylate (CAS 75985-18-1)
- Des-Gln24-Tirzepatide (CAS CATO-CPTD788949)
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