3-Hydroxy-6-methyl-3-(trifluoromethyl)indolin-2-one CAS 128350-88-9

Purity 97%+In StockPharmaceutical Standards
CAS No.128350-88-9
Molecular FormulaC10H8F3NO2
Molecular Weight231.17 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

3-Hydroxy-6-methyl-3-(trifluoromethyl)indolin-2-one CAS 128350-88-9 chemical structure

Description

The occurrence of 3-Hydroxy-6-methyl-3-(trifluoromethyl)indolin-2-one is closely related to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

3-Hydroxy-6-methyl-3-(trifluoromethyl)indolin-2-one (CAS 128350-88-9) is a high-purity analytical reference standard with the molecular formula C10H8F3NO2 and a molecular weight of 231.17 g/mol.

3-Hydroxy-6-methyl-3-(trifluoromethyl)indolin-2-one (C10H8F3NO2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 3-Hydroxy-6-methyl-3-(trifluoromethyl)indolin-2-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC10H8F3NO2
Molecular Weight231.17 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in chloroform, dichloromethane, ethyl acetate, DMSO
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions
Degree of Unsaturation (DBE)6.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1993
Halogen ContentF-containing
Nitrogen Atoms1

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