3-(Difluoromethoxy)-2,4,5-trifluorobenzoic acid CAS 128426-86-8
| CAS No. | 128426-86-8 |
| Molecular Formula | C8H3F5O3 |
| Molecular Weight | 242.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(Difluoromethoxy)-2,4,5-trifluorobenzoic acid (CAS 128426-86-8), molecular formula C8H3F5O3 and molecular weight 242.10 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 3-(Difluoromethoxy)-2,4,5-trifluorobenzoic acid (C8H3F5O3) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 242.10 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-(Difluoromethoxy)-2,4,5-trifluorobenzoic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C8H3F5O3 |
| Molecular Weight | 242.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 1-(2-(Difluoromethoxy)phenyl)-2,2,2-trifluoroethan-1-ol (CAS 1251088-23-9)
- 1-(Difluoromethoxy)-4-methyl-2-(trifluoromethoxy)benzene (CAS 1261748-50-8)
- 1-(4-(Difluoromethoxy)phenyl)-2,2,2-trifluoroethan-1-ol (CAS 150698-83-2)
- 1-(3-(Difluoromethoxy)phenyl)-2,2,2-trifluoroethan-1-ol (CAS 2229294-07-7)
- 3-(Difluoromethoxy)-5-methylbenzofuran-2-carboxylic acid (CAS 1708401-49-3)
- 3-(Difluoromethoxy)-7-methylbenzofuran-2-carboxylic acid (CAS 1774901-76-6)
- 5-[4-(Difluoromethoxy)-3-methoxyphenyl]-2H-tetrazole (CAS 832739-31-8)
- 4-[4-(difluoromethoxy)phenyl]-1,3-thiazol-2-amine (CAS 105512-78-5)
Recommended Standards
- 1-(2-Chlorobenzyl)-4-(chloromethyl)-1H-1,2,3-triazole (CAS 1250020-19-9)
- 2,3-Difluoro-4-(trifluoromethoxy)benzoic acid (CAS 1309597-49-6)
- 1-(2-Chloro-4-methylphenyl)-4-(chloromethyl)-1H-1,2,3-triazole (CAS 1248480-71-8)
- 4,7-Dichloro-6-methoxy-2-methylquinoline (CAS 1315346-63-4)
- 1-Propanamine, 3-(isodecyloxy)- (CAS 30113-45-2)
- Ethyl 3-(4-mercaptophenyl)acrylate (CAS 1076198-07-6)
- {1-[2-chloro-5-(trifluoromethyl)phenyl]cyclopropyl}methanamine (CAS 1797582-14-9)
- Thiourea-<SUP>13</SUP>C (CAS 113899-66-4)
- 2-(2-Hydroxyethyl)-6-phenylpyridazin-3(2H)-one (CAS 23916-77-0)
- 1-Methyl-4-(piperidine-1-sulfonyl)-1h-pyrrole-2-carboxylic acid (CAS 937625-15-5)
- Diethyl n-butylmalonate (CAS 133-08-4)
- 2-Hydroxy-2-(5-methylfuran-2-yl)-1-phenylethanone (CAS 613652-96-3)
- N-Cyclopropyl-4-fluoro-N-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)benzamide (CAS 606095-19-6)
- Semaglutide impurity 267 (CAS CATO-C4X-2226267)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com