Ethyl 4-chloropyrido[4,3-d]pyrimidine-2-carboxylate CAS 1286330-20-8
| CAS No. | 1286330-20-8 |
| Molecular Formula | C10H8ClN3O2 |
| Molecular Weight | 237.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Ethyl 4-chloropyrido[4,3-d]pyrimidine-2-carboxylate (CAS 1286330-20-8), molecular formula C10H8ClN3O2 and molecular weight 237.64 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Ethyl 4-chloropyrido[4,3-d]pyrimidine-2-carboxylate is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 237.64 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H8ClN3O2 |
| Molecular Weight | 237.64 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Ethyl Standards
- Ethyl 4-chloropyrido[3,2-d]pyrimidine-2-carboxylate (CAS 1286330-10-6)
- Ethyl 4-chloropyrido[2,3-d]pyrimidine-2-carboxylate (CAS 1286330-18-4)
- 4-(2-Chloropyrido[2,3-d]pyrimidin-4-yl)morpholine (CAS 908142-01-8)
- 4-(2-Chloropyrido[3,2-d]pyrimidin-4-yl)morpholine (CAS 53840-89-4)
- 4-(7-Chloropyrido[4,3-d]pyrimidin-4-yl)morpholine (CAS 915190-39-5)
- Methyl 4-chloropyrido[3,4-d]pyrimidine-2-carboxylate (CAS 1220039-65-5)
- Methyl 4-chloropyrido[2,3-d]pyrimidine-2-carboxylate (CAS 1260761-86-1)
- Methyl 7-chloropyrido[2,3-d]pyrimidine-4-carboxylate (CAS 2306277-66-5)
Recommended Standards
- 1-(6-Chloropyridazin-3-yl)-4-methyl-1H-pyrrole-3-carboxylic acid (CAS 1330753-18-8)
- 4-Chloro-pyrido[3,4-d]pyrimidine-2-carboxylic acid ethyl ester (CAS 1286330-15-1)
- Methyl 7-chloro-4-oxo-1,4-dihydroquinoline-3-carboxylate (CAS 133514-23-5)
- Methyl 2-chloro-6-(4H-1,2,4-triazol-4-yl)benzoate (CAS 1351382-27-8)
- 3-(4-methyl-1,3-thiazol-2-yl)pyridine (CAS 39067-27-1)
- Ethyl 6-(3,5-dimethoxyphenyl)-6-oxohexanoate (CAS 898758-65-1)
- 2-Bromo-3’,4’-dimethoxyacetophenone (CAS 1835-02-5)
- (3R)-1-Benzhydryl-2,2-dimethyl-azetidin-3-ol (CAS 2227199-05-3)
- 2,7-Dibromo-9,9’-spirobifluorene (CAS 171408-84-7)
- 3-(4-Methoxyphenyl)-5,6-dimethyl-2-sulfanylthieno[2,3-d]pyrimidin-4(3h)-one (CAS 65234-06-2)
- 3-[(4-Chloro-1-naphthyl)oxy]azetidine (CAS 1220028-48-7)
- N-(4-bromo-2,6-difluorophenyl)-2-chloroacetamide (CAS 646989-59-5)
- Octadecanoic-4,4-d (CAS 62690-13-5)
- A-18-F-NH2; Morphine Modulating Neuropeptide (CAS 99588-52-0)
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