2-Iodo-3-trifluoromethyl-pyrazine CAS 1286744-15-7
| CAS No. | 1286744-15-7 |
| Molecular Formula | C5H2F3IN2 |
| Molecular Weight | 273.98 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 2-Iodo-3-trifluoromethyl-pyrazine (C5H2F3IN2) is characterized by a nitrile group, fluorine/iodine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
2-Iodo-3-trifluoromethyl-pyrazine (CAS 1286744-15-7) is a high-purity analytical reference standard with the molecular formula C5H2F3IN2 and a molecular weight of 273.98 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H2F3IN2 |
| Molecular Weight | 273.98 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/I-containing |
| Nitrogen Atoms | 2 |
Related Iodo Standards
- 3-Iodo-5-(trifluoromethyl)pyridazine (CAS 1049024-00-1)
- 2-Iodo-5-(trifluoromethyl)pyrimidine (CAS 112930-95-7)
- 3-Iodo-6-(trifluoromethyl)pyridazine (CAS 1206524-33-5)
- 4-Iodo-6-(trifluoromethyl)pyrimidine (CAS 1209314-40-8)
- 5-Iodo-4-(trifluoromethyl)pyrimidine (CAS 1260843-81-9)
- 2-Iodo-4-(trifluoromethyl)pyrimidine (CAS 1379347-59-7)
- 2-Iodo-6-(trifluoromethyl)pyrazine, 97% (CAS 141492-94-6)
- 5-Iodo-2-(trifluoromethyl)pyrimidine (CAS 1443533-55-8)
Recommended Standards
- 4-Iodo-2-(trifluoromethyl)pyrimidine (CAS 1807056-81-0)
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- 2-bromo-1-(3,5-dichlorophenyl)ethan-1-one (CAS 53631-13-3)
- Bis(trimethylsilyl)telluride, 98% (CAS 4551-16-0)
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- 1-Tert-butoxycarbonyl-3,4,5,6,7,7a-hexahydro-2H-cyclopenta[b]pyridine-4a-carboxylic acid (CAS 2241142-12-9)
- 1,5,6,7-Tetrahydropyrido[2,3-d]pyrimidin-4-amine (CAS 69278-04-2)
- 2,6-Bis(1-imidazolyl)pyridine (CAS 39242-17-6)
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