5-Fluoro-4-hydroxynicotinaldehyde CAS 1289068-72-9
| CAS No. | 1289068-72-9 |
| Molecular Formula | C6H4FNO2 |
| Molecular Weight | 141.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Fluoro-4-hydroxynicotinaldehyde.
5-Fluoro-4-hydroxynicotinaldehyde (CAS 1289068-72-9), molecular formula C6H4FNO2 and molecular weight 141.10 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 5-Fluoro-4-hydroxynicotinaldehyde (C6H4FNO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 5-Fluoro-4-hydroxynicotinaldehyde meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H4FNO2 |
| Molecular Weight | 141.10 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
- 6-Fluoro-5-hydroxypicolinaldehyde (CAS 1211585-11-3)
- 3-Fluoro-5-hydroxypicolinaldehyde (CAS 1227515-00-5)
- 2-Fluoro-6-hydroxyisonicotinaldehyde (CAS 1227580-31-5)
- 5-Fluoro-6-hydroxynicotinaldehyde (CAS 1227605-77-7)
- 4-Fluoro-5-hydroxypicolinaldehyde (CAS 1256791-67-9)
- 6-Fluoro-[1,3]dioxolo[4,5-b]pyridine (CAS 1260667-36-4)
- 5-Fluoro-2-oxo-1,2-dihydropyridine-3-carbaldehyde (CAS 917391-98-1)
- 6-Fluoro-2-pyridinecarboxylic Acid (CAS 402-69-7)
Recommended Standards
- 5-Fluoropyrimidine-2-carboxamide (CAS 1378675-45-6)
- 3-Fluoropyridine-2-carboxylic Acid (CAS 152126-31-3)
- 4-Fluoronicotinic Acid (CAS 152126-33-5)
- 3-Fluoropyrazine-2-carboxamide (CAS 1623099-47-7)
- Duoperone (CAS 62030-88-0)
- 3-Oxo-4-(4-methylphenyl)butanoyl chloride (CAS 1989983-07-4)
- Tetraethyl Orthosilicate (CAS 78-10-4)
- (4-Methyl-2-oxo-1,2,3,4-tetrahydroquinoxalin-6-yl)boronic acid (CAS 305790-80-1)
- 2-Methyl-4-(trimethylsilyl)but-3-yn-2-ol (CAS 5272-33-3)
- 1-(3,4-Dimethoxyphenyl)-4-oxocyclohexanecarboxylic Acid (CAS 887978-64-5)
- 2-(oxetan-3-yl)ethanethiol (CAS 1896796-99-8)
- 2-(Pyrrolidin-1-yl)pyridin-4-amine (CAS 35981-63-6)
- 5-(3-Nitrophenyl)-1,3,4-oxadiazol-2-amine (CAS 7659-02-1)
- Tyr-Proinsulin C-Peptide (55-89) (human) (CAS 139532-11-9)
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