(2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite CAS 129451-77-0
| CAS No. | 129451-77-0 |
| Molecular Formula | C45H61N4O9PSi |
| Molecular Weight | 861.05 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (C45H61N4O9PSi) contains a nitrogen-containing heterocyclic scaffold, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage. It is notably hygroscopic, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
(2R,3R,4R,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-2-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (CAS 129451-77-0), molecular formula C45H61N4O9PSi and molecular weight 861.05 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C45H61N4O9PSi |
| Molecular Weight | 861.05 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 17.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 4 |
Recommended Standards
- (2R,3R,4S,5R)-2-(6-((19-Amino-4,7,10,13,16-pentaoxanonadecyl)amino)-9H-purin-9-yl)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)tetrahydrofuran-3,4-diol (CAS 869354-92-7)
- (2S,3S,4S,5S)-2-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3-yl (2-cyanoethyl) diisopropylphosphoramidite (CAS 144490-31-3)
- Lurbinectedin Impurity 26 (CAS 497871-49-5)
- 2'-O-TBDMS-Pseudouridine (CAS 163496-23-9)
- Ethyl 5-methyl-2-((2-(trifluoromethyl)phenyl)amino)thiazole-4-carboxylate (CAS 2197063-15-1)
- 3-Methyl-2-phenylbenzofuran (CAS 4521-08-8)
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- 2,7-Dimethylquinoline-5,8-dione (CAS 64636-84-6)
- (1-Methyl-1h-pyrazol-4-yl)methanethiol (CAS 1248624-50-1)
- N-benzyl-1-(3,4-dichlorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxamide (CAS 338754-35-1)
- Semaglutide impurity 47 (CAS CATO-C4X-222647)
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