2-Amino-5-(trifluoromethyl)adamantane-2-carboxylic acid hydrochloride CAS 1303974-01-7
| CAS No. | 1303974-01-7 |
| Molecular Formula | C12H16F3NO2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Amino-5-(trifluoromethyl)adamantane-2-carboxylic acid hydrochloride (CAS 1303974-01-7) is a high-purity analytical reference standard with the molecular formula C12H16F3NO2HCl and a molecular weight of 299.72 g/mol.
The molecular framework of 2-Amino-5-(trifluoromethyl)adamantane-2-carboxylic acid hydrochloride (C12H16F3NO2HCl) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Amino-5-(trifluoromethyl)adamantane-2-carboxylic acid hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H16F3NO2 HCl |
| Molecular Weight | 299.72 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- Oxazolidinethione Impurity 3 (CAS 68831-68-5)
- n-(Sec-butyl)-4-ethyl-1,2,3-thiadiazole-5-carboxamide (CAS 1197661-76-9)
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- 3-(difluoromethyl)-1-methyl-1H-thieno[2,3-c]pyrazole-5-carboxylic acid (CAS 1339640-88-8)
- 2-isoxazol-5-yl-4-methylphenol (CAS 104516-57-6)
- (1R,3S)-3-(4-amino-1H-pyrazol-1-yl)cyclohexan-1-ol (CAS 1819990-60-7)
- CAS 2043952-58-3 (CAS 2043952-58-3)
- 2-Bromo-1-ethoxy-3-(trifluoromethyl)benzene (CAS 1089192-49-3)
- tert-Butyl 4-oxo-2-phenylpyrrolidine-1-carboxylate (CAS 1546332-56-2)
- Semaglutide impurity 272 (CAS CATO-C4X-2226272)
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