Ethyl 1-benzyl-4,4-difluoropiperidine-3-carboxylate CAS 1303974-56-2
| CAS No. | 1303974-56-2 |
| Molecular Formula | C15H19F2NO2 |
| Molecular Weight | 283.31 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 283.31 g/mol gives Ethyl 1-benzyl-4,4-difluoropiperidine-3-carboxylate distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Ethyl 1-benzyl-4,4-difluoropiperidine-3-carboxylate (CAS 1303974-56-2), a certified reference material (molecular formula C15H19F2NO2, MW 283.31 g/mol) for analytical method development and quality control.
The molecular framework of Ethyl 1-benzyl-4,4-difluoropiperidine-3-carboxylate (C15H19F2NO2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H19F2NO2 |
| Molecular Weight | 283.31 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- Ethyl 1-Benzyl-3,3-difluoropiperidine-4-carboxylate (CAS 1303972-84-0)
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- N-(Piperidin-4-ylmethyl)pyrimidin-2-amine hydrochloride (CAS 1185314-62-8)
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