(1R,3s,5S)-tert-Butyl 3-(methylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate CAS 1307254-45-0
| CAS No. | 1307254-45-0 |
| Molecular Formula | C13H24N2O2 |
| Molecular Weight | 240.34 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including (1R,3s,5S)-tert-Butyl 3-(methylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate.
(1R,3s,5S)-tert-Butyl 3-(methylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate (CAS 1307254-45-0), molecular formula C13H24N2O2 and molecular weight 240.34 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (1R,3s,5S)-tert-Butyl 3-(methylamino)-8-azabicyclo[3.2.1]octane-8-carboxylate (C13H24N2O2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H24N2O2 |
| Molecular Weight | 240.34 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1990 |
| Nitrogen Atoms | 2 |
Recommended Standards
- 4-Phenyl-2-(pyridin-2-yl)pentan-1-amine (CAS 1306606-05-2)
- (4-Ethoxypiperidin-1-yl)(piperidin-4-yl)methanone (CAS 1307282-44-5)
- 4-Phenyl-2-(pyridin-4-yl)pentan-1-amine (CAS 1306605-43-5)
- Tert-butyl 3-(methylamino)-8-azabicyclo[3.2.1]Octane-8-carboxylate (CAS 1308222-30-1)
- 8-Chloro-3,4-dihydroquinazolin-4-one (CAS 101494-95-5)
- 1-(2-Oxoindolin-5-yl)-3-(p-tolyl)urea (CAS 1171576-53-6)
- (2R,3S,4R,5R)-2-(Hydroxymethyl)-5-(6-mercapto-2-phenyl-9H-purin-9-yl)tetrahydrofuran-3,4-diol (CAS 56489-66-8)
- (3R,4S)-4-(4-bromophenyl)pyrrolidine-3-carboxylic acid (CAS 1217978-04-5)
- 5-((3-Fluorophenyl)amino)-3,3-dimethyl-5-oxopentanoic acid (CAS 1011454-07-1)
- 3-Propyldihydrofuran-2,5-dione (CAS 14035-82-6)
- (2R,2'R,3R,3'R)-WingPhos (CAS 1884680-45-8)
- (2S,3S)-3-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-hydroxy-3-(3-methoxyphenyl)propanoic acid (CAS 959576-00-2)
- 4-Amino-n-(1-{bicyclo[2.2.1]heptan-2-yl}ethyl)benzene-1-sulfonamide, mixture of diastereomers (CAS 1005090-06-1)
- Semaglutide impurity 235 (CAS CATO-C4X-2226235)
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