3-Chloro-2-[2-(4-chloro-benzenesulfonyl)-2H-pyrazol-3-yl]-5-trifluoromethyl-pyridine CAS 1311277-99-2
| CAS No. | 1311277-99-2 |
| Molecular Formula | C15H8Cl2F3N3O2S |
| Molecular Weight | 422.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 422.21 g/mol gives 3-Chloro-2-[2-(4-chloro-benzenesulfonyl)-2H-pyrazol-3-yl]-5-trifluoromethyl-pyridine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
3-Chloro-2-[2-(4-chloro-benzenesulfonyl)-2H-pyrazol-3-yl]-5-trifluoromethyl-pyridine (CAS 1311277-99-2), molecular formula C15H8Cl2F3N3O2S and molecular weight 422.21 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-Chloro-2-[2-(4-chloro-benzenesulfonyl)-2H-pyrazol-3-yl]-5-trifluoromethyl-pyridine (C15H8Cl2F3N3O2S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-Chloro-2-[2-(4-chloro-benzenesulfonyl)-2H-pyrazol-3-yl]-5-trifluoromethyl-pyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H8Cl2F3N3O2S |
| Molecular Weight | 422.21 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 4-Chloro-5-{4-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}-2-ethyl-2,3-dihydropyridazin-3-one (CAS 320421-65-6)
- (5-Chloro-1-methyl-3-((phenylthio)methyl)-1H-pyrazol-4-yl)methyl (4-chlorophenyl)carbamate (CAS 400087-21-0)
- 4-Chloro-5,6-diiodothieno[2,3-d]pyrimidine (CAS 1799610-91-5)
- 3-[(2-Chloro-6-fluorophenyl)methyl]-1-dodecyl-4-hydroxy-1,2-dihydropyridin-2-one (CAS 477860-64-3)
- N-(3-Chloro-2-methylphenyl)-2-((3-ethyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 335399-64-9)
- N-(5-Chloro-2-methylphenyl)-2-((3-ethyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 585552-97-2)
- N-(3-chloro-4-methylphenyl)-2-(2-((phenylthio)methyl)-1H-benzo[d]imidazol-1-yl)acetamide (CAS 339100-68-4)
- 2-(4-chloro-2-methylphenoxy)(3-pyridyl) 4-benzylpiperazinyl ketone (CAS 497060-64-7)
Recommended Standards
- (2E)-2-(2,4-Dichlorobenzenesulfonyl)-3-{[5-(trifluoromethyl)pyridin-2-yl]amino}prop-2-enenitrile (CAS 1025208-17-6)
- (3-(Trifluoromethyl)-1-trityl-1H-pyrazol-4-yl)boronic acid (CAS 474706-58-6)
- 6-Bromo-2-{2-[3-(trifluoromethyl)phenyl]ethenyl}quinoline-4-carboxylic acid (CAS 926269-29-6)
- Ethyl 6-(benzyloxy)-7-iodo-1H-indazole-1-carboxylate (CAS 2767589-67-1)
- Benzo[c][1,2,5]oxadiazole-4,7-diamine (CAS 215860-46-1)
- (2-(Aminomethyl)-6-fluorospiro[3.3]heptan-2-yl)methanol hydrochloride (CAS 2715120-08-2)
- 1-Cyclohexyl-3-phenylurea (CAS 886-59-9)
- 5-Bromo-2,4-dimethylpyrimidine (CAS 69696-37-3)
- 2-Chloromethyl-3-methoxy-6-(trifluoromethyl)pyridine (CAS 1227606-47-4)
- 4-Fluoro-2-methyl-6-nitroaniline (CAS 147285-87-8)
- 2-(2-(Difluoromethoxy)-5-methylbenzoyl)pyridine (CAS 1261799-43-2)
- 2-Fluoro-4-(thiophen-2-yl)benzoic acid (CAS 505082-90-6)
- 6-Aminoquinoline-2-carboxylic acid (CAS 124551-31-1)
- Tau Peptide (401-411)-Lys-Lys trifluoroacetate salt (CAS 2022956-59-6)
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