4-[3-(6-Dimethylamino-4-trifluoromethyl-pyridin-2-yl)-phenyl]-pyrimidin-2-ylamine CAS 1311279-85-2
| CAS No. | 1311279-85-2 |
| Molecular Formula | C18H16F3N5 |
| Molecular Weight | 359.35 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-[3-(6-Dimethylamino-4-trifluoromethyl-pyridin-2-yl)-phenyl]-pyrimidin-2-ylamine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-[3-(6-Dimethylamino-4-trifluoromethyl-pyridin-2-yl)-phenyl]-pyrimidin-2-ylamine (CAS 1311279-85-2), a certified reference material (molecular formula C18H16F3N5, MW 359.35 g/mol) for analytical method development and quality control.
Structurally, 4-[3-(6-Dimethylamino-4-trifluoromethyl-pyridin-2-yl)-phenyl]-pyrimidin-2-ylamine (C18H16F3N5) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 359.35 g/mol, it falls into the moderately-high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H16F3N5 |
| Molecular Weight | 359.35 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 5 |
Related Dimethylamino Standards
- 4-[4-(6-Dimethylamino-4-trifluoromethyl-pyridin-2-yl)-phenyl]-pyrimidin-2-ylamine (CAS 1311279-70-5)
- N-(2-(Dimethylamino)-2-(thiophen-2-yl)ethyl)-1-(methylsulfonyl)piperidine-4-carboxamide (CAS 1209961-43-2)
- 4-[4-(Dimethylamino)-1-(4’-chlorophenyl)-1-hydroxybutyl]-3-(hydroxymethyl)-benzonitrile (CAS 1076200-05-9)
- 1-[2-(2-Dimethylamino-5-iodo-pyrimidin-4-yl)-pyrrolidin-1-yl]-ethanone (CAS 1361115-97-0)
- 1-(3-((Dimethylamino)methyl)-1,4-thiazepan-4-yl)-2-(naphthalen-2-yloxy)ethan-1-one (CAS 1448050-33-6)
- 4-{[4-(dimethylamino)phenyl]methylidene}-1,2,3,4-tetrahydroacridine-9-carboxylic acid (CAS 379728-16-2)
- 4-[3-(6-Dimethylamino-4-trifluoromethyl-pyridin-2-yl)-phenyl]-pyrimidin-2-ol (CAS 1311279-04-5)
- 4-[4-(6-Dimethylamino-4-trifluoromethyl-pyridin-2-yl)-phenyl]-pyrimidin-2-ol (CAS 1311279-78-3)
Recommended Standards
- 4-Defluoro-4-(1H-1,2,4-triazol-1-yl) Fluconazole-d4 (CAS 1794817-03-0)
- N2,N2-dibenzyl-6-(trifluoromethyl)-1,3,5-triazine-2,4-diamine (CAS 122600-54-8)
- 1-(Cyanomethyl)-N-(4-(trifluoromethyl)phenyl)-3,4-dihydroisoquinoline-2(1H)-carboxamide (CAS 339011-97-1)
- 2-([1,1'-Biphenyl]-4-yl)-6-fluoro-3-hydroxyquinoline-4-carboxylic acid (CAS 122262-72-0)
- Methyl 3-bromo-2-(difluoromethoxy)-5-isopropylbenzoate (CAS 2404733-63-5)
- Tert-butyl (1S,4S)-6-amino-2-azabicyclo[2.2.1]Heptane-2-carboxylate (CAS 1933764-12-5)
- 2,4-Difluoro-6-nitrobenzyl chloride (CAS 1803809-32-6)
- 2-Butylundecanoic acid (CAS 66241-54-1)
- [3-(1-Piperidin-1-ylcyclohexyl)phenyl]aminehydrochloride (CAS 1211430-30-6)
- (R)-2-Amino-4-oxopentanoic acid (CAS 772325-69-6)
- 8-Bromo-2,6-dimethylimidazo[1,2-a]pyrazin-3-amine (CAS 1935499-45-8)
- 1-(Furan-2-yl)pentane-1,3-dione (CAS 157589-73-6)
- N-(4-Nitro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)ethanamine (CAS 2377610-58-5)
- Urotensin II-Related Peptide (human, mouse, rat) (CAS 342878-90-4)
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