Methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)acetate CAS 1313377-99-9
| CAS No. | 1313377-99-9 |
| Molecular Formula | C16H14ClN3O2 |
| Molecular Weight | 315.75 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)acetate.
Methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)acetate (CAS 1313377-99-9) is a high-purity analytical reference standard with the molecular formula C16H14ClN3O2 and a molecular weight of 315.75 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, Methyl 2-(7-chloro-5-methyl-2-phenylpyrazolo[1,5-a]pyrimidin-6-yl)acetate is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 315.75 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H14ClN3O2 |
| Molecular Weight | 315.75 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
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Recommended Standards
- 2-((Tert-butoxycarbonyl)amino)-3-(4-chlorophenyl)-3-hydroxypropanoic acid (CAS 1263093-86-2)
- Ethyl 2-(2-chlorophenyl)-7-methylpyrazolo[1,5-a]pyrimidine-6-carboxylate (CAS 1332506-36-1)
- (S)-3-(2-(3-Chlorophenyl)acetyl)-4-phenyloxazolidin-2-one (CAS 1332528-96-7)
- 4-Allyl-2-(5-chloro-2H-benzo[d][1,2,3]triazol-2-yl)-6-methoxyphenol (CAS 1260141-20-5)
- N-Nitroso-N-methyl-3-aminopropionic Acid-d3, Methyl Ester (CAS 1246815-46-2)
- 4-Diethylaminomethyl-5-ethyl-furan-2-carboxylic acid hydrochloride 844882-34-4 (CAS 844882-34-4)
- 4-Chloro-5-(4-fluorophenyl)-7-(4-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidine (CAS 907585-55-1)
- 2-((Ethylamino)methyl)-N,N-dimethylaniline (CAS 1095231-83-6)
- 4-[[2-Methyl-6-(trifluoromethyl)-3-pyridinyl]amino]-4-oxo-2-butenoic acid (CAS 402479-90-7)
- 4-Fluoro-3-methylpiperidine hydrochloride (CAS 1781143-46-1)
- (3R,4R)-Methyl 4-(trifluoromethyl)pyrrolidine-3-carboxylate hydrochloride (CAS 2140264-93-1)
- 5-Phenyl-1,3-oxazole-2-thiol (CAS 16172-23-9)
- sec-Butylcyclopropane (CAS 5750-02-7)
- semaglutide (CAS 782487-28-9)
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