1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-5-(difluoromethyl)-3-methyl-1H-pyrazole-4-carboxylic acid CAS 1315367-73-7
| CAS No. | 1315367-73-7 |
| Molecular Formula | C12H7ClF5N3O2 |
| Molecular Weight | 355.65 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 355.65 g/mol gives 1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-5-(difluoromethyl)-3-methyl-1H-pyrazole-4-carboxylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-5-(difluoromethyl)-3-methyl-1H-pyrazole-4-carboxylic acid (CAS 1315367-73-7) is a high-purity analytical reference standard with the molecular formula C12H7ClF5N3O2 and a molecular weight of 355.65 g/mol.
1-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]-5-(difluoromethyl)-3-methyl-1H-pyrazole-4-carboxylic acid (C12H7ClF5N3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H7ClF5N3O2 |
| Molecular Weight | 355.65 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related chloro Standards
- 3-chloro-5-(trifluoromethyl)-2-{[3-(trifluoromethyl)phenoxy]methyl}pyridine (CAS 648427-32-1)
- (3Z)-6-Chloro-3-[(2,4-dichlorophenyl)methylidene]-3,4-dihydro-2H-1-benzothiopyran-4-one (CAS 866143-74-0)
- 1-(5-Chloro-1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-(3-(trifluoromethyl)phenyl)methanimine (CAS 648859-67-0)
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- 4-Chloro-2-(2,4-dichlorobenzyl)-6-methyl-1H-pyrrolo[3,4-c]pyridine-1,3(2H)-dione (CAS 261363-78-4)
- 3-Chloro-5-(p-tolyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (CAS 348148-51-6)
- 4-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)-2-methylbenzo[f][1,3,4]oxadiazepin-5(4H)-one (CAS 861210-70-0)
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Recommended Standards
- 2,4,5-T-Butoxyethyl Ester (CAS 2545-59-7)
- 1-(4-Bromobenzyl)-2-butyl-4-chloro-1H-imidazole-5-carbaldehyde (CAS 143722-29-6)
- N,N′,N′′-Trihexyldiethylenetriamine (CAS 250787-15-6)
- 7-Bromo-5-(2-chlorophenyl)-1,3-dihydro-2H-thieno[2,3-e]-1,4-diazepin-2-one (CAS 40017-65-0)
- 2-(4-Chloro-3-methylbutyl)thiophene (CAS 1339483-48-5)
- Ethyl 2-(4-oxo-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-3(4H)-yl)acetate (CAS 40277-49-4)
- 2-(4-(4-Fluorophenyl)thiazol-2-yl)acetamide (CAS 342405-30-5)
- ethyl 2-((3,5,6-trichloropyridin-2-yl)oxy)acetate (CAS 60825-27-6)
- 2-((5-(4-(tert-Butyl)phenyl)-4-(4-methoxyphenyl)-4H-1,2,4-triazol-3-yl)thio)-N-(2,4-dichlorophenyl)acetamide (CAS 477313-55-6)
- 3-Trifluoromethanesulfonamidobenzoic acid (CAS 546115-64-4)
- 5666-12-6 Phosphorous acid tripyrrolidide Tripyrrolidinophosphine Tris(N,N-tetramethylene)phosphorous acid triamide (CAS 5666-12-6)
- Ethyl 4-(Aminomethyl)benzoate Hydrochloride (CAS 6232-12-8)
- 3-(Pyrrolidin-2-yl)benzonitrile hydrochloride (CAS 1203683-21-9)
- [His]1-Acetylated Semaglutide (CAS CATO-C4X-2226219)
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