4-[1-(difluoromethyl)-1h-imidazol-2-yl]aniline CAS 1315369-01-7
| CAS No. | 1315369-01-7 |
| Molecular Formula | C10H9F2N3 |
| Molecular Weight | 209.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
4-[1-(difluoromethyl)-1h-imidazol-2-yl]aniline (CAS 1315369-01-7) is a high-purity analytical reference standard with the molecular formula C10H9F2N3 and a molecular weight of 209.20 g/mol.
4-[1-(difluoromethyl)-1h-imidazol-2-yl]aniline (C10H9F2N3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H9F2N3 |
| Molecular Weight | 209.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1990 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related difluoromethyl Standards
- 2-(Difluoromethyl)-N-methylquinazolin-4-amine (CAS 1247454-62-1)
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- 3-(Difluoromethyl)-4-(1H-pyrazol-1-yl)aniline (CAS 1341571-90-1)
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Recommended Standards
- Ethyl 7-Oxo-4,5,6,7-tetrahydro-2H-pyrazolo[3,4-c]pyridine-3-carboxylate (CAS 1313532-55-6)
- N-Formyl-L-tyrosine (CAS 13200-86-7)
- 3-Amino-5-(ethoxycarbonyl)benzoic acid (CAS 1312425-07-2)
- N-(4-Methoxybenzoyl)glycine (CAS 13214-64-7)
- ((1-(tert-Butoxycarbonyl)piperidin-4-yl)methyl)triphenylphosphonium iodide (CAS 146293-11-0)
- 5-Oxo-4,5,6,7-tetrahydro-1H-imidazo[4,5-b]pyridine-6-carboxylic acid (CAS 1263178-26-2)
- Methyl (E)-3-(2-(3-chloro-5-(trifluoromethyl)pyridin-2-yl)hydrazono)-2-(1H-1,2,4-triazol-1-yl)propanoate (CAS 551930-85-9)
- 2,5-Dimethylbenzaldehyd-2,4-dinitrophenylhydrazone (CAS 152477-96-8)
- tert-Butyl ((R)-1-((S)-2-methylpyrrolidin-1-yl)propan-2-yl)carbamate (CAS 2036332-77-9)
- 6-Aminopyridine-3-boronic Acid Hydrochloride (CAS 1309982-15-7)
- Ceftazidime Impurity 85 (CAS CATO-C4X-121285)
- (Z)-Methyl 2-(1-(2-chlorophenyl)-4-((3-(dimethylamino)phenyl)(methylamino)methylene)-5-oxo-4,5-dihydro-1H-pyrazol-3-yl)acetate (CAS 1820587-57-2)
- H-Gly-Gly-Ala-Gly-OH (CAS 23654-88-8)
- Des-Ala21-Tirzepatide (CAS CATO-CPTD788952)
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