Paricalcitol Impurity 2 CAS 132015-95-3
| CAS No. | 132015-95-3 |
| Molecular Formula | C27H44O3 |
| Molecular Weight | 416.64 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Paricalcitol Impurity 2.
Paricalcitol Impurity 2 (CAS 132015-95-3) is a certified pharmaceutical impurity reference standard with the molecular formula C27H44O3 and a molecular weight of 416.64 g/mol.
Structurally, Paricalcitol Impurity 2 (C27H44O3) contains a steroid core, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 416.64 g/mol, it falls into the moderately-high-molecular-weight range. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C27H44O3 |
| Molecular Weight | 416.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
Related Paricalcitol Standards
- Paricalcitol 22-Z (CAS CATO-C4X-13871)
- Paricalcitol Impurity 3 (CAS 1884139-61-0)
- Paricalcitol (CAS 131918-61-1)
- Paricalcitol Impurity 38 (CAS CATO-C4X-138738)
- Paricalcitol Impurity 4 (CAS 2230789-87-2)
- Paricalcitol Impurity 43 (CAS CATO-C4X-138743)
- Paricalcitol Impurity 5 (CAS CATO-C4X-13875)
- Paricalcitol Impurity 8 (CAS CATO-C4X-13878)
Recommended Standards
- Ceftazidime impurity 126 (CAS CATO-C4X-1212126)
- 18-Norcholan-24-oic acid, 3,20-dihydroxy-4,4,8,14-tetramethyl-,g-lactone, (3b,5a)- 35833-72-8 (CAS 35833-72-8)
- Vitamin D3 Impurity 11 (CAS 915160-17-7)
- Tacalcitol EP Impurity B (CAS 57333-95-6)
- Gentamicin Impurity 12 (CAS 25876-11-3)
- Pilocarpine Impurity 11 (CAS CATO-C4X-240111)
- Gemcitabine Impurity 14 (CAS 294177-31-4)
- 54646-38-7 Benzothiazolium,3-ethyl-2-[5-(3-ethyl-2(3H)-benzothiazolylidene)-1,3-pentadien-1-yl]-, chloride(1:1) CTK5A2057 (CAS 54646-38-7)
- imidazo[1,2-c]pyrimidine-2-carbaldehyde (CAS 1019029-68-5)
- 3-(Trifluoromethyl)tetrahydrofuran-3-amine hydrochloride (CAS 1638269-35-8)
- 1-(3-Chloropropyl)-5-methyl-1h-1,2,3,4-tetrazole (CAS 870833-61-7)
- 2-Isopropyl-5-methylaniline (CAS 2437-39-0)
- 2-(Trifluoromethyl)-1H-benzo[d]imidazole-6-carbaldehyde (CAS 106429-45-2)
- Semaglutide impurity 251 (CAS CATO-C4X-2226251)
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