8-Benzyl-4-(2,5-difluorobenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid CAS 1326811-64-6
| CAS No. | 1326811-64-6 |
| Molecular Formula | C22H22F2N2O4 |
| Molecular Weight | 416.42 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
8-Benzyl-4-(2,5-difluorobenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326811-64-6) is a high-purity analytical reference standard with the molecular formula C22H22F2N2O4 and a molecular weight of 416.42 g/mol.
Owing to a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution, 8-Benzyl-4-(2,5-difluorobenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 416.42 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 8-Benzyl-4-(2,5-difluorobenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H22F2N2O4 |
| Molecular Weight | 416.42 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Benzyl Standards
- 8-Benzyl-4-(2,4-difluorobenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326811-14-6)
- 8-Benzyl-4-(3,5-difluorobenzoyl)-1-oxa-4,8-diazaspiro[4.5]decane-3-carboxylic acid (CAS 1326812-12-7)
- 3-{[4-(2,6-difluorobenzoyl)-3-methyl-2-oxo-1,2,3,4-tetrahydroquinoxalin-1-yl]methyl}benzonitrile (CAS 317833-44-6)
- 1-(2,5-Difluorobenzoyl)-4-{[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine (CAS 1775306-06-3)
- 1-(3,4-Difluorobenzoyl)-4-{[3-(3-methoxyphenyl)-1,2,4-oxadiazol-5-yl]methyl}piperidine (CAS 1775399-29-5)
- 3-[1-(2,6-Difluorobenzoyl)piperidin-4-yl]-4-[(4-methylphenyl)methyl]-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775397-13-1)
- 4-(2,6-Difluorobenzoyl)-1-(3-methoxybenzyl)-3-methyl-3,4-dihydroquinoxalin-2(1H)-one (CAS 317833-52-6)
- 4-(2,6-Difluorobenzoyl)-1-[(4-methoxyphenyl)methyl]-3-methyl-1,2,3,4-tetrahydroquinoxalin-2-one (CAS 317833-54-8)
Recommended Standards
- (2R,3R,4S,5S,6R)-2-Phenethoxy-6-((((2S,3R,4S,5R)-3,4,5-trihydroxytetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-3,4,5-triol (CAS 129932-48-5)
- Khelloside (CAS 17226-75-4)
- Tert-butyl (R)-(5-(2-fluoro-5-nitrophenyl)-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2H-1,2,4-thiadiazin-3-yl)carbamate (CAS 1286776-27-9)
- Felbamate Dimer (CAS 1796927-91-7)
- Methyl 2-(chlorosulfonyl)furan-3-carboxylate (CAS 1011241-51-2)
- 2,4,7-Trimethoxyquinoline-3-carbaldehyde (CAS 51179-20-5)
- Methyl 2,4-Dihydroxyphenylacetate (CAS 67828-42-6)
- 2-Hydroxy-7-methoxyquinoline-3-carbonitrile (CAS 116704-99-5)
- 3-(1-(2,4-Dimethylphenyl)-3-methyl-5-oxo-4,5-dihydro-1h-pyrazol-4-yl)propanoic acid (CAS 1204298-02-1)
- 2-Amino-5-(4-fluorophenyl)furan-3-carbonitrile (CAS 708976-50-5)
- 3-((4-Aminopiperidin-1-yl)methyl)phenol (CAS 946679-47-6)
- Vilanterol Impurity 7 (CAS CATO-C4X-19357)
- N-(2-(Dimethylamino)ethyl)-3-phenylquinoxaline-5-carboxamide (CAS 107027-31-6)
- Fibrinopeptide A (human) (CAS 25422-31-5)
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