6-Amino-5-(2-chlorophenyl)pyrimidine-2(1H)-thione CAS 13291-72-0
| CAS No. | 13291-72-0 |
| Molecular Formula | C10H8ClN3S |
| Molecular Weight | 237.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
6-Amino-5-(2-chlorophenyl)pyrimidine-2(1H)-thione (CAS 13291-72-0), molecular formula C10H8ClN3S and molecular weight 237.71 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-Amino-5-(2-chlorophenyl)pyrimidine-2(1H)-thione (C10H8ClN3S) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, sulfur-containing functionality, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 6-Amino-5-(2-chlorophenyl)pyrimidine-2(1H)-thione meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H8ClN3S |
| Molecular Weight | 237.71 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Amino Standards
- 2-Amino-5-(2-chlorophenyl)pyrimidine-4-thiol (CAS 15937-38-9)
- (2-amino-5-chlorophenyl)(thiophen-2-yl)methanone (CAS 41631-21-4)
- 2-Amino-3-(2-chlorobenzoyl)thiophene (CAS 40017-58-1)
- (2-Amino-5-chlorophenyl)(cyclohexyl)methanone (CAS 1789-30-6)
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- 6-(3-Amino-4-chlorophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one (CAS 124939-47-5)
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- 1-[4-(2-Methoxyethoxy)phenyl]piperazine (CAS 515160-72-2)
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- 1-(Methoxymethyl)cyclopropanecarbonitrile (CAS 1267146-97-3)
- N-Nitroso N-Desmethyl DEBA (CAS CATO-C4X-135126)
- (S)-1,3,3-Triphenylhexahydropyrrolo-[1,2-c][1,3,2]oxazaborole (CAS 131180-90-0)
- <I>N,N</I>-dimethyl ethyl oxalate (CAS 16703-52-9)
- 3-(p-Tolyl)furan-2,5-dione (CAS 3152-16-7)
- 2-Chloro-N-(3-methylbenzyl)benzamide (CAS 710318-31-3)
- 2-Bromoisophthaldehyde (CAS 79839-49-9)
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