(3R,4S)-1-(tert-butoxycarbonyl)-4-(3,5-difluorophenyl)pyrrolidine-3-carboxylic acid CAS 1329835-75-7
| CAS No. | 1329835-75-7 |
| Molecular Formula | C16H19F2NO4 |
| Molecular Weight | 327.32 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 327.32 g/mol gives (3R,4S)-1-(tert-butoxycarbonyl)-4-(3,5-difluorophenyl)pyrrolidine-3-carboxylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
(3R,4S)-1-(tert-butoxycarbonyl)-4-(3,5-difluorophenyl)pyrrolidine-3-carboxylic acid (CAS 1329835-75-7), molecular formula C16H19F2NO4 and molecular weight 327.32 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (3R,4S)-1-(tert-butoxycarbonyl)-4-(3,5-difluorophenyl)pyrrolidine-3-carboxylic acid (C16H19F2NO4) is characterized by a flavonoid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures (3R,4S)-1-(tert-butoxycarbonyl)-4-(3,5-difluorophenyl)pyrrolidine-3-carboxylic acid under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H19F2NO4 |
| Molecular Weight | 327.32 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- N-(5-(1-Methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazol-2-yl)benzo[c][1,2,5]thiadiazole-5-carboxamide (CAS 1219904-47-8)
- ethyl 5,5-difluoro-1-(4-methoxybenzyl)-4-oxopiperidine-3-carboxylate (CAS 1423027-26-2)
- Flubendazole EP Impurity F (CAS 132119-20-1)
- 3-Benzyl-8-(trifluoromethyl)-3,4-dihydro-2H,6H-pyrimido[2,1-b][1,3,5]thiadiazin-6-one (CAS 1426894-90-7)
- 4-(4-(Pyridin-2-yl)pyrimidin-2-yl)phenyl furan-2-carboxylate (CAS 477857-31-1)
- 2-(1-Phenyl-1h-pyrazol-4-yl)cyclopropan-1-amine (CAS 1157139-81-5)
- 2-((4-Methylbenzyl)thio)-1H-benzo[d]imidazole (CAS 352333-42-7)
- 3-(5-Methylfuran-2-yl)isoxazol-5-amine (CAS 1042641-10-0)
- 5-(Trifluoromethyl)-1H-benzo[d][1,2,3]triazole (CAS 1548-67-0)
- 7-Chloro-3-(propan-2-yl)-2-sulfanyl-3,4-dihydroquinazolin-4-one (CAS 422526-50-9)
- Ethyl 2-methyl-6-nitroimidazo[1,2-a]pyridine-3-carboxylate (CAS 81438-60-0)
- Cytarabine Impurity 27 (CAS CATO-C4X-200527)
- Telmisartan Sodium (CAS 515815-47-1)
- Semaglutide Impurity 148 (CAS CATO-C4X-2226148)
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