Loratadine EP Impurity A CAS 133284-74-9
| CAS No. | 133284-74-9 |
| Molecular Formula | C22H25ClN2O3 |
| Molecular Weight | 400.90 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Loratadine EP Impurity A is closely related to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
As a process- or degradation-related impurity, Loratadine EP Impurity A (CAS 133284-74-9, C22H25ClN2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Loratadine EP Impurity A (C22H25ClN2O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Loratadine EP Impurity A under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C22H25ClN2O3 |
| Molecular Weight | 400.90 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Loratadine Standards
- Loratadine Impurity 39 (CAS CATO-C4X-142639)
- Loratadine Impurity N9 (CAS 107256-32-6)
- Loratadine EP Impurity F (CAS 125743-80-8)
- Loratadine Epoxide (CAS 1189694-51-6)
- Loratadine impurity 11 (CAS 165739-62-8)
- Loratadine Impurity 35 (CAS CATO-C4X-142635)
- Loratadine Impurity 37 (CAS CATO-C4X-142637)
- Loratadine Impurity 38 (CAS 403484-49-1)
Recommended Standards
- Tert-butyl (2-chlorobenzyl) (6-hydroxyhexane-1,5-diyl)(S)-dicarbamate (CAS 198476-84-5)
- 5-(2-Chlorophenyl)-2-mercapto-3-(2-methoxyphenyl)thieno[2,3-d]pyrimidin-4(3h)-one (CAS 743452-23-5)
- 2-Chloro-3-[4-(3-methylpiperidine-1-carbonyl)piperidin-1-yl]-1,4-dihydronaphthalene-1,4-dione (CAS 439108-69-7)
- 1-(4-Chlorophenethyl)-3-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-yl)thiourea (CAS 502579-32-0)
- Dopamine Impurity 44 (CAS CATO-C4X-190844)
- Lenvatinib Impurity 152 (CAS CATO-C4X-1140152)
- Cefpodoxime Proxetil EP Impurity G (CAS 947692-15-1)
- Methabenzthiazuron (CAS 18691-97-9)
- 1-(4-((6-Chloropyrazin-2-yl)methyl)piperidin-1-yl)ethan-1-one (CAS 1316223-72-9)
- tert-Butyl 5-bromo-8-iodo-3,4-dihydroisoquinoline-2(1H)-carboxylate (CAS 2922795-09-1)
- 4-Fluorobenzofuran-3(2H)-one (CAS 911826-36-3)
- 1-[2-hydroxy-3-(methylamino)propyl]pyrrolidin-2-one (CAS 1019476-49-3)
- (E)-3-(4-chloro-3-ethoxy-2-fluorophenyl)acrylic acid (CAS 1324063-26-4)
- Liraglutide(10-22)TFA Salt (CAS CATO-C4X-199211)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com