2-Bromo-1-nitro-3,5-bis(trifluoromethyl)benzene CAS 133307-04-7
| CAS No. | 133307-04-7 |
| Molecular Formula | C8H2BrF6NO2 |
| Molecular Weight | 338.00 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Bromo-1-nitro-3,5-bis(trifluoromethyl)benzene.
2-Bromo-1-nitro-3,5-bis(trifluoromethyl)benzene (CAS 133307-04-7), molecular formula C8H2BrF6NO2 and molecular weight 338.00 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, 2-Bromo-1-nitro-3,5-bis(trifluoromethyl)benzene is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 338.00 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H2BrF6NO2 |
| Molecular Weight | 338.00 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 2-Bromo-5-nitro-1,3-bis(trifluoromethyl)benzene (CAS 1365643-24-8)
- 1-Bromo-2-nitro-4,5-bis(trifluoromethyl)benzene (CAS 229957-08-8)
- 7-Bromo-2-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazole (CAS 2377607-31-1)
- Methyl 5-bromo-4-(bromomethyl)-2-methoxybenzoate (CAS 1075281-18-3)
- 5-Bromo-2-bromomethyl-4-methoxy-benzoic acid methyl ester (CAS 1965310-34-2)
- 2-Bromo-1-(2-bromo-4,5-dimethoxyphenyl)ethanone (CAS 321681-28-1)
- 2-Bromo-1-(4-bromo-2,5-dimethoxy-phenyl)ethanone (CAS 807631-08-9)
- 3-Bromo-4-(2-bromoethoxy)-5-methoxybenzaldehyde (CAS 219685-47-9)
Recommended Standards
- 2,8-dibromophenaZine (CAS 105836-93-9)
- 3,8-Dibromo-1,10-phenanthroline (CAS 100125-12-0)
- 4,7-Dibromo-1,10-phenanthroline (CAS 156492-30-7)
- Ethyl 2-(2,4-dibromophenoxy)acetate (CAS 90798-55-3)
- 1,5-Dinitroanthracene-9,10-dione (CAS 82-35-9)
- 2-Hydroxy-2-methyl-3-phenylmethanesulfonyl-N-[4-(trifluoromethyl)phenyl]propanamide (CAS 338956-15-3)
- {3-[(2-Methyl-1H-imidazol-1-yl)methyl]phenyl}methanamine (CAS 953751-31-0)
- 4-(5,7-Dioxo-5,7-dihydro-6H-pyrrolo[3,4-b]pyrazin-6-yl)benzoic acid (CAS 37460-93-8)
- N-(4-Acetyl-6-cyanopyridin-2-yl)acetamide (CAS 1393546-45-6)
- Ifosfamide EP Impurity E (CAS 42453-19-0)
- 3-(Chloromethyl)-6-methylpyridazine (CAS 1056644-40-6)
- 5-(4-Fluorophenyl)oxazole (CAS 128101-19-9)
- 4-(1H-Pyrrol-1-yl)-N-(thiazol-2-yl)butanamide (CAS 1257550-85-8)
- Semaglutide impurity 47 (CAS CATO-C4X-222647)
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