1-[6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazol-1-yl]ethanone CAS 1333319-78-0
| CAS No. | 1333319-78-0 |
| Molecular Formula | C15H26BFN2O3 |
| Molecular Weight | 312.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 1-[6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazol-1-yl]ethanone.
1-[6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazol-1-yl]ethanone (CAS 1333319-78-0) is a high-purity analytical reference standard with the molecular formula C15H26BFN2O3 and a molecular weight of 312.19 g/mol.
The molecular framework of 1-[6-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)indazol-1-yl]ethanone (C15H26BFN2O3) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C15H26BFN2O3 |
| Molecular Weight | 312.19 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.5 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- 1-(Tetrahydro-1,1-dioxido-3-thienyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 1233526-31-2)
- N,N-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine-3-sulfonamide (CAS 1416337-91-1)
- 5-Bromo-N-((2-methylthiazol-4-yl)methyl)nicotinamide (CAS 1223237-60-2)
- 2-(2-Methoxy-5-(methylsulfonyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1496547-56-8)
- 2-(Piperidin-4-yl)-6-(trifluoromethyl)pyridine (CAS 473932-18-2)
- [(E)-2-(2,4-Dinitrophenyl)ethenyl]dimethylamine (CAS 61293-29-6)
- 1-(Azepan-1-yl)-2-(4-(4-(thiophen-2-yl)pyrimidin-2-yl)phenoxy)ethan-1-one (CAS 477889-43-3)
- N-2-Hydroxyethyl-N-(methyl-d3)-p-toluenesulfonamide (CAS 854634-39-2)
- 3-Benzyloxy-2-chloro-6-fluorophenylboronic acid (CAS 957062-67-8)
- 4-Bromo-1-(pyridin-4-ylmethyl)pyrazole (CAS 1179798-11-8)
- 3-Amino-5,5-dimethylpyrrolidin-2-one (CAS 1445655-56-0)
- 1-(Piperidine-1-carbonyl)piperidine-4-carboxamide (CAS 923106-63-2)
- 2-(piperidin-4-yl)pyrazine dihydrochloride (CAS 1803582-75-3)
- Copper Peptide ·2 acetate salt (CAS 130120-57-9)
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