Cyclopropyl(4-(trifluoromethoxy)phenyl)methanone CAS 133333-78-5
| CAS No. | 133333-78-5 |
| Molecular Formula | C11H9F3O2 |
| Molecular Weight | 230.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Cyclopropyl(4-(trifluoromethoxy)phenyl)methanone.
Cyclopropyl(4-(trifluoromethoxy)phenyl)methanone (CAS 133333-78-5), molecular formula C11H9F3O2 and molecular weight 230.18 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, Cyclopropyl(4-(trifluoromethoxy)phenyl)methanone (C11H9F3O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 230.18 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H9F3O2 |
| Molecular Weight | 230.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | F-containing |
Related Cyclopropyl Standards
- 2-Cyclopropyl-4-(trifluoromethyl)benzoic acid (CAS 1236303-04-0)
- cyclopropyl[3-(trifluoromethoxy)phenyl]methanone (CAS 1341065-96-0)
- 3-Cyclopropyl-4-(trifluoromethoxy)benzaldehyde (CAS 2830621-06-0)
- 3-Cyclopropyl-5-(trifluoromethoxy)benzaldehyde (CAS 2444272-12-0)
- N-Cyclopropyl-6-(trifluoromethyl)pyridine-3-carboxamide (CAS 1092346-00-3)
- 2-(5-Cyclopropyl-3-(difluoromethyl)-1h-pyrazol-1-yl)acetohydrazide (CAS 1004644-16-9)
- Ethyl 1-cyclopropyl-3-(difluoromethyl)-1H-pyrazole-5-carboxylate (CAS 2540503-48-6)
- 4-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)benzoic acid (CAS 1165931-66-7)
Recommended Standards
- 3-Amino-1-(5-nitropyridin-2-yl)-1h-pyrazole-4-carbonitrile (CAS 1311313-99-1)
- 6-(2-Methoxyphenyl)-3,4-dihydronaphthalen-1(2H)-one (CAS 1262388-29-3)
- 2-Bromo-4-(trimethylsilyl)pyridine (CAS 134391-66-5)
- 6-(Trifluoromethoxy)-3,4-dihydronaphthalen-1(2H)-one (CAS 1260019-45-1)
- 2-Oxo-1',2',5',6',7',7a'-hexahydrospiro[indoline-3,3'-pyrrolizine]-2'-carboxylic acid (CAS 1265964-44-0)
- (R)-3,3'-Bis([1,1':3',1''-terphenyl]-5'-yl)-[1,1'-binaphthalene]-2,2'-diol (CAS 1539285-81-8)
- 8-(Trifluoromethyl)quinoline-5-carbaldehyde (CAS 2089310-78-9)
- 6-Benzyl-4,5,6,7-tetrahydrofuro[2,3-c]pyridine-2-carboxylic acid (CAS 1194374-63-4)
- Ethyl (E)-3-[5-(hydroxymethyl)pyridin-2-yl]acrylate (CAS 1018673-94-3)
- 3-(2-Isopropyl-5-methylphenoxy)azetidine (CAS 1220028-38-5)
- 2-Amino-4-((5-chloro-6-methyl-2-(methylsulfonyl)pyrimidin-4-yl)amino)benzenesulfonic acid (CAS 69304-83-2)
- 1-(Pyrrolo[1,2-d][1,2,4]triazin-1-yl)piperidine-3-carboxylic acid (CAS 1713463-15-0)
- Ethyl 4-oxo-4,9a-dihydro-1H-pyrimido[1,2-a]pyrimidine-3-carboxylate (CAS 40519-95-7)
- (Ser(PO?H?)2?2)-Tau Peptide (260-264) PAb Blocking trifluoroacetate salt (CAS 2022956-57-4)
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