6-Bromo-8-chloro-[1,2,4]triazolo[4,3-a]pyrazine CAS 1334135-75-9
| CAS No. | 1334135-75-9 |
| Molecular Formula | C5H2BrClN4 |
| Molecular Weight | 233.45 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
6-Bromo-8-chloro-[1,2,4]triazolo[4,3-a]pyrazine (CAS 1334135-75-9) is a high-purity analytical reference standard with the molecular formula C5H2BrClN4 and a molecular weight of 233.45 g/mol.
Owing to a nitrile group, chlorine/bromine substitution, 6-Bromo-8-chloro-[1,2,4]triazolo[4,3-a]pyrazine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 233.45 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C5H2BrClN4 |
| Molecular Weight | 233.45 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 4 |
Related Bromo Standards
- 5-Bromo-2-chlorooxazolo[4,5-b]pyridine (CAS 1211533-63-9)
- 6-Bromo-4-chlorofuro[3,2-d]pyrimidine (CAS 1211536-97-8)
- 7-Bromo-4-chlorofuro[3,2-d]pyrimidine (CAS 1211595-48-0)
- 8-Bromo-5-chloro-[1,2,4]triazolo[1,5-c]pyrimidine (CAS 1367774-82-0)
- 2-Bromo-6-chloro-3-hydroxyisonicotinonitrile (CAS 1445968-08-0)
- 6-Bromo-2-chloro-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 1779766-69-6)
- 5-Bromo-4-chloroimidazo[5,1-f][1,2,4]triazine (CAS 1780012-72-7)
- 4-Bromo-2-chlorooxazolo[4,5-c]pyridine (CAS 1780666-94-5)
Recommended Standards
- 2,6-Di(<I>tert</I>-butyl-1-d<SUB>1</SUB>)-4-methyl-d<SUB>3</SUB>-phenol-3,5- d<SUB>2</SUB> (BHT) (CAS 1219805-62-5)
- 2,4,6-Trichloro-5-(difluoromethyl)pyrimidine (CAS 1807617-93-1)
- 2-Chloro-3-(dichloromethyl)-2-butenedioic Acid (cis and trans mixture) (CAS 122551-90-0)
- 6-Bromo-2-chlorooxazolo[5,4-b]pyridine (CAS 1782797-89-0)
- 5-(2,4-dichlorophenyl)-4-isobutyl-4H-1,2,4-triazole-3-thiol (CAS 743452-43-9)
- N-(5-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)propan-2-amine (CAS 2096336-54-6)
- N-(2-Chlorophenyl)-4-(pyrrolidin-1-ylsulfonyl)benzamide (CAS 313403-51-9)
- 2-(2,3-Dichlorophenoxy)-2-phenylacetic acid (CAS 938116-95-1)
- 4-(AMINOMETHYL)PYRIDIN-3-AMINE DIHYDROCHLORIDE (CAS 847666-49-3)
- Methyl (2R,4S)-4-Cbz-aminopyrrolidine-2-carboxylate hydrochloride (CAS 1279026-46-8)
- 1-Benzyl-3-bromo-5-methoxy-1H-1,2,4-triazole (CAS 1415719-60-6)
- 5-((tert-Butoxycarbonyl)amino)-1,3,4-oxadiazole-2-carboxylic acid (CAS 1258411-54-9)
- 1-Cyclopropyl-3-(2-methylphenyl)piperazine (CAS 1248907-48-3)
- Semaglutide impurity 211 (CAS CATO-C4X-2226211)
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