Tert-butyl 4,4-difluoro-3-(2-hydroxyethyl)piperidine-1-carboxylate CAS 1334413-29-4
| CAS No. | 1334413-29-4 |
| Molecular Formula | C12H21F2NO3 |
| Molecular Weight | 265.30 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Tert-butyl 4,4-difluoro-3-(2-hydroxyethyl)piperidine-1-carboxylate (CAS 1334413-29-4), molecular formula C12H21F2NO3 and molecular weight 265.30 g/mol, is a CATO reference standard with documented purity and traceability.
Tert-butyl 4,4-difluoro-3-(2-hydroxyethyl)piperidine-1-carboxylate (C12H21F2NO3) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures Tert-butyl 4,4-difluoro-3-(2-hydroxyethyl)piperidine-1-carboxylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H21F2NO3 |
| Molecular Weight | 265.30 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1991 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- Tert-butyl 3,3-difluoro-4-(hydroxymethyl)-4-methylpiperidine-1-carboxylate (CAS 1334412-58-6)
- Tert-butyl 3,3-difluoro-4-(2-hydroxyethyl)piperidine-1-carboxylate (CAS 1334415-93-8)
- 4-(2-((tert-Butoxycarbonyl)amino)ethyl)benzoic acid (CAS 132690-91-6)
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