Alprostadil (Prostaglandin E1) EP Impurity B CAS 13345-51-2
| CAS No. | 13345-51-2 |
| Molecular Formula | C20H32O4 |
| Molecular Weight | 336.47 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Alprostadil (Prostaglandin E1) EP Impurity B (CAS 13345-51-2) is a certified pharmaceutical impurity reference standard with the molecular formula C20H32O4 and a molecular weight of 336.47 g/mol.
The molecular framework of Alprostadil (Prostaglandin E1) EP Impurity B (C20H32O4) is characterized by a steroid core, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C20H32O4 |
| Molecular Weight | 336.47 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at room temperature, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1960 |
Related Alprostadil Standards
- Alprostadil (Prostaglandin E1) EP Impurity A (CAS 14152-28-4)
- Alprostadil EP Impurity C (CAS 22973-19-9)
- Alprostadil EP Impurity G (CAS 363-24-6)
- Alprostadil EP Impurity F (CAS 21003-46-3)
- 11-beta-Alprostadil (Prostaglandin E1) (CAS 24570-01-2)
- Alprostadil (Prostaglandin E1) Impurity 5 (PGE0) (CAS 19313-28-1)
- Alprostadil (Prostaglandin E1) EP Impurity I (CAS 35900-16-4)
- Alprostadil EP Impurity K (CAS 791-28-6)
Recommended Standards
- Tiamulin impurity 22 (CAS 442681-88-1)
- 4-Methyl-N-((1-(thiophen-2-ylmethyl)piperidin-4-yl)methyl)-1,2,3-thiadiazole-5-carboxamide (CAS 1210517-42-2)
- Neodymium(III) oxide (CAS 1313-97-9)
- Darunavir Impurity 41 (CAS 388073-93-6)
- Nilestrio Unknown Impurity 1 (CAS CATO-CPS-2602001)
- Vitamin K1 Impurity 32 (CAS 4444-13-7)
- Toremifene impurity 9 Citrate (CAS 89778-29-0 (free base))
- 7-Chloro-1H-1,8-naphthyridin-2-one (CAS 15944-34-0)
- Ethyl 2-(2-chloroacetamido)-4-(4-methoxyphenyl)thiophene-3-carboxylate (CAS 356568-71-3)
- Amlodipine Impurity 107 (CAS CATO-C4X-1095107)
- 5-Benzylidene-1H-imidazol-4(5H)-one (CAS 955377-79-4)
- 5-(2-Chlorophenyl)furan-2-carboxylic acid (CAS 41019-43-6)
- 4-Chloro-2-ethoxy-6-(trifluoromethyl)pyrimidine (CAS 932701-91-2)
- Semaglutide Impurity 139 (CAS CATO-C4X-2226139)
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