Nevirapine Impurity 4 CAS 133627-46-0
| CAS No. | 133627-46-0 |
| Molecular Formula | C12H9Cl2N3O |
| Molecular Weight | 282.13 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 282.13 g/mol gives Nevirapine Impurity 4 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Nevirapine Impurity 4 (CAS 133627-46-0), a pharmacopoeial impurity reference standard (molecular formula C12H9Cl2N3O, MW 282.13 g/mol) used for the identification and quantification of trace impurities in APIs.
Based on its molecular formula C12H9Cl2N3O, Nevirapine Impurity 4 contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 282.13 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a certified reference material (CRM), Nevirapine Impurity 4 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H9Cl2N3O |
| Molecular Weight | 282.13 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1995 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Nevirapine Standards
- Nevirapine 3-Hydroxy Impurity (CAS 174532-82-2)
- Nevirapine N1-Oxide (CAS 162255-73-4)
- Nevirapine 3-Ethenyl (CAS 284686-22-2)
- Nevirapine-d5DISCONTINUED See N391278 (CAS 1189717-29-0)
- Nevirapine 3-Formyl Impurity (CAS 174532-77-5)
- Nevirapine-d3 (CAS 1051419-24-9)
- Nevirapine EP Impurity C (CAS 287980-85-2)
- Nevirapine impurity 8 (CAS CATO-C4X-17098)
Recommended Standards
- 6-Cyano-trans-3-bromo-3,4-dihydro-2,2-dimethyl-2H-benzo-[b]-pyran-4-ol 65018-89-5 trans-3-Bromo-3,4-dihydro-4-hydroxy-2,2-dimethyl-2H-1-benzopyran-6-carbonitrile (CAS 65018-89-5)
- 1-(4-Bromophenyl)-α,α-dimethyl-1H-1,2,3-triazole-4-methanol (CAS 1000339-34-3)
- N-(4-Bromobutyl)phthalimide 2-(4-bromobutyl)-1h-isoindole-1,3(2h)-dione n-(4-bromobutyl) phthalimide n-(4-bromobutyl)-phthalimide 5394-18-3 (CAS 5394-18-3)
- 1-(2-(Methoxymethoxy)ethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole (CAS 1013101-73-9)
- Ezetimibe Impurity 87 (CAS 1197343-07-9)
- Cytarabine EP Impurity F (CAS 32830-01-6)
- Mizolastine impurity 12 (CAS CATO-C4X-200612)
- Ethyl 1-(methoxymethyl)-4-oxocyclohexanecarboxylate (CAS 1284852-92-1)
- N-(Cyclohexylmethyl)-2-[(8-Fluoro-5-Methyl-5H-1,2,4-Triazino[5,6-b]Indol-3-ylThio]-Acetamide (CAS 603948-19-2)
- Levodopa Impurity 29 (CAS CATO-C4X-167629)
- Tert-butyl (2-(ethylsulfonyl)ethyl)carbamate (CAS 595596-96-6)
- 2,8-dibromo-[1,2,4]triazolo[1,5-a]pyridine (CAS 1257705-07-9)
- 1-(Thiophen-2-yl)cyclopropan-1-ol (CAS 888505-23-5)
- Tau Peptide (306-317) trifluoroacetate salt (CAS 1003007-59-7)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com